ArticleProgress in orthodontics2025
Integrative multi-omics and causal inference reveal periodontal ligament cell-macrophage crosstalk under orthodontic force.
Article in Progress in orthodontics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- The mechano-immune-vesicle regulatory circuit: a systems framework for bone homeostasis and regeneration.Bioactive materials · 2026Review
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Authors and funding
6 authors.
Funding
Abstract
backgroundOrthodontic tooth movement requires synchronized mechanoadaptive and osteoimmune interactions, yet molecular pathways linking mechanical forces to immune-mediated bone remodeling remain incompletely characterized. This study aimed to elucidate molecular drivers and dissect cell crosstalk under orthodontic force, with a focus on their immunoregulatory consequences.
methodsThis study combined in vitro compressive loading of human periodontal ligament (PDL) cells with transcriptomic/proteomic profiling, and in vivo single-cell RNA sequencing of alveolar bone macrophages from murine orthodontic models. Mendelian randomization (MR) analysis leveraged genetic instruments from transcriptome-wide (n = 31,684), proteome-wide (n = 35,559), and immune trait genome-wide association studies (n = 3,757). The two-phase framework first identified mechanoresponsive molecular signatures across omics layers, then established causal links to immune cell dynamics through MR.
resultsTranscriptomic and proteomic analyses of PDL cells under compressive force revealed LBH upregulation and TGF-β pathway activation and collagen disassembly, evidenced by COL1A1/COL2A1 downregulation. Single-cell RNA sequencing identified Cd40
conclusionsOrthodontic forces induce transcriptional reprogramming and proteomic remodeling in PDL cells, which drive CD40 signaling in monocytes through mechano-immunological coupling. These adaptations activate Cd40
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