Evidence map›Paper›PMID 41115067›Full record

ArticleJournal of applied physiology (Bethesda, Md. : 1985)2025

Intermuscular adipose tissue in healthy human aging-effects of exercise training and implications to metabolic health.

Andrew M Alexander, Lucy M Fitzgibbons, Hawley E Kunz, Zinnarky K Ortiz Correa, K Sreekumaran Nair, John Port, Ian R Lanza

Abstract read
In one paragraph

Article in Journal of applied physiology (Bethesda, Md. : 1985), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Andrew M AlexanderDivision of Endocrinology, Mayo Clinic, Rochester, Minnesota, United States.
Lucy M FitzgibbonsDivision of Endocrinology, Mayo Clinic, Rochester, Minnesota, United States.
Hawley E KunzDivision of Endocrinology, Mayo Clinic, Rochester, Minnesota, United States.ORCID 0000-0002-4291-4455
Zinnarky K Ortiz CorreaDivision of Endocrinology, Mayo Clinic, Rochester, Minnesota, United States.
K Sreekumaran NairDivision of Endocrinology, Mayo Clinic, Rochester, Minnesota, United States.ORCID 0000-0002-0649-9469
John PortDivision of Radiology, Mayo Clinic, Rochester, Minnesota, United States.
Ian R LanzaDivision of Endocrinology, Mayo Clinic, Rochester, Minnesota, United States.ORCID 0000-0002-9858-3384

Funding

Enhancing Adaptations to ExerciseR01AG054454 · NIA · MAYO CLINIC ROCHESTER · PI LANZA, IAN R · 2017 to 2022
$3.3M
Mechanisms of Anabolic Resistance in Older HumansR01AG084733 · NIA · MAYO CLINIC ROCHESTER · PI IAN R LANZA · 2024 to 2026
$2.0M
HHS | NIH | National Institute on Aging (NIA) AG054454HHS | NIH | National Institute on Aging (NIA) AG084733NIA NIH HHS R01 AG054454NIA NIH HHS R01 AG084733
6 · The paper itself

Abstract

Intermuscular adipose tissue (IMAT) is an anatomically distinct depot that is associated with metabolic dysfunction and aging. IMAT decreases with exercise in older adults with obesity, but less is known about how exercise influences IMAT in healthy, nonobese older adults in relation to insulin sensitivity. The purpose of this study was to determine whether lower leg IMAT accumulates in healthy older adults in the absence of obesity, diabetes, or frailty and its relationship to insulin sensitivity. We also determined the influence of exercise training on lower leg IMAT. Twenty-nine young (25.0 ± 3.8 yr) and 22 older (76.0 ± 5.0 yr) adults underwent MRI-based measurements of lower leg IMAT and insulin sensitivity measurements by hyperinsulinemic euglycemic clamp before and after 12 wk of exercise training. IMAT was higher in older compared with young adults (2,512 ± 1,178 mm

Indexed as

Adipose TissueAgingExerciseMuscle, SkeletalAdultAgedFemaleGlucose Clamp TechniqueHumansInsulin ResistanceMaleYoung Adultagingexercise traininginsulin sensitivityintermuscular adipose tissueskeletal muscle

Identifiers

PMID41115067
PMCPMC12582400

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.