ArticleJournal of applied physiology (Bethesda, Md. : 1985)2025
Hypohydration augments the acute increase in urinary biomarkers of kidney injury following the 100-mile Western States Endurance Run.
Article in Journal of applied physiology (Bethesda, Md. : 1985), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed, 1 synthesis or guideline pooled it.
- TheFrontiers in physiology · 2026Pooled it
- Eight weeks of MitoQ supplementation does not alter kidney function or urinary kidney injury biomarkers in middle-aged and older adults.American journal of physiology. Renal physiology · 2026Trial
- Water intake mediates cross-sectional associations between urinary kidney injury biomarkers and race in emerging adults.American journal of physiology. Regulatory, integrative and comparative physiology · 2026Article
- Physiology of lived experience: Cruising among the Swiss peaks.Experimental physiology · 2026Article
- Biomarker-driven risk stratification and early intervention in acute kidney injury: a comprehensive review from early warning to clinical response.Frontiers in medicine · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
Abstract
Ultraendurance races may transiently increase acute kidney injury (AKI) risk, yet data on contributing factors are sparse. Therefore, we examined the acute effects of the Western States Endurance Run [WSER (100 miles; 161 km)] on urinary AKI biomarkers and kidney blood flow, while also assessing the influence of race pace and hydration status. Blood and urine samples were collected to assess urine specific gravity (USG), creatinine, and AKI risk [nephrin, neutrophil gelatinase-associated lipocalin (NGAL), insulin-like growth factor binding protein 7 (IGFBP7), tissue inhibitor of metalloproteinase 2 (TIMP2), and IGFBP-7·TIMP-2]. Renal blood velocity and conductance were measured via Doppler ultrasonography. Pre and post measures were obtained from 36 runners (29 males/7 females, age: 44 ± 9 yr, mean finish time: 25:45:55). Urinary AKI biomarkers increased postrace, with nephrin, IGFBP7, and IGFBP7·TIMP-2 remaining elevated after indexing to creatinine (
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.