Evidence mapPaperPMID 41115902Full record

ArticleSignal transduction and targeted therapy2025

Condensate nanovaccine adjuvants augment CD8

Yu Tang, Zhiyuan Luo, Zhanni Ma, Lingling Han, Yurong Zhou, Tianci Liang, Kangsen Yang, Lei Zhao, Xiaoyuan Chen, Pengfei Zhang

Abstract read
In one paragraph

Article in Signal transduction and targeted therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Nanovaccines for lung cancer: Platforms, mechanistic insights, and translational challenges.Chinese medical journal pulmonary and critical care medicine · 2026
    Review
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yu Tang *Institute of Molecular Immunology, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou, China.
Zhiyuan Luo *Innovation Research Institute of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Zhanni Ma *Institute of Molecular Immunology, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou, China.
Lingling Han *Institute of Molecular Immunology, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou, China.
Yurong Zhou *Department of Radiology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei Province, China.
Tianci LiangInstitute of Molecular Immunology, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou, China.
Kangsen YangInstitute of Molecular Immunology, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou, China.
Lei ZhaoDepartment of Orthopedics, Air Force Hospital of Eastern Theater of PLA, Nanjing, China.
Xiaoyuan ChenDepartments of Diagnostic Radiology, Surgery, Chemical and Biomolecular Engineering, Biomedical Engineering, Clinical Imaging Research Centre, Pharmacy and Pharmaceutical Sciences, and Nanomedicine Translational Research Program, Yong Loo Lin School of Medicine and Faculty of Engineering, National University of Singapore, Singapore, Singapore. chen.shawn@nus.edu.sg.ORCID 0000-0002-9622-0870
Pengfei ZhangInstitute of Molecular Immunology, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou, China. zpf0418@i.smu.edu.cn.ORCID 0000-0003-1186-5950

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The variety and functionality of current clinical vaccine adjuvants remain limited. Conventional aluminum-based adjuvants predominantly induce Th2-biased humoral immunity but exhibit a limited capacity to elicit Th1-mediated cellular immune responses, particularly tumor antigen-specific cytotoxic CD8

Indexed as

Adjuvants, ImmunologicAdjuvants, VaccineCancer VaccinesCD8-Positive T-LymphocytesDNA, MitochondrialMembrane ProteinsNucleotidyltransferasesAnimalsCyclic Guanosine Monophosphate-Adenosine Monophosphate SynthaseHumansMiceNanoparticlesNanovaccinesSTING ProteinAdjuvants, ImmunologicAdjuvants, VaccineCancer VaccinescGAS protein, mouseCyclic Guanosine Monophosphate-Adenosine Monophosphate SynthaseDNA, MitochondrialMembrane ProteinsNanovaccinesNucleotidyltransferasesSting1 protein, mouseSTING Protein

Identifiers

PMID41115902
PMCPMC12537970

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.