Evidence map›Paper›PMID 41115989›Full record

SynthesisGastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association2026

Burden of gastric cancer attributable to Helicobacter pylori in 27 countries from seven geographic regions in 2022.

Giulia Collatuzzo, Elton Dajti, Matteo Secco, Franco Bazzoli, Paolo Boffetta, Rocco Maurizio Zagari

Abstract readSystematic ReviewMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
  4. Limitations of Helicobacter pylori-attributable gastric cancer estimates in Albania.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2026
    Article
  5. Review
  6. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Giulia CollatuzzoDepartment of Medical and Surgical Sciences, University of Bologna, Via Massarenti, 9. 40138, Bologna, Italy.
Elton DajtiDepartment of Medical and Surgical Sciences, University of Bologna, Via Massarenti, 9. 40138, Bologna, Italy.
Matteo SeccoGastroenterology and Digestive Endoscopy Unit, Michele e Pietro Ferrero Hospital, Verduno, Cuneo, Italy.
Franco BazzoliDepartment of Medical and Surgical Sciences, University of Bologna, Via Massarenti, 9. 40138, Bologna, Italy.
Paolo BoffettaDepartment of Medical and Surgical Sciences, University of Bologna, Via Massarenti, 9. 40138, Bologna, Italy.
Rocco Maurizio ZagariDepartment of Medical and Surgical Sciences, University of Bologna, Via Massarenti, 9. 40138, Bologna, Italy. roccomaurizio.zagari@unibo.it.ORCID 0000-0001-9949-8619

Funding

Alma Mater Studiorum
6 · The paper itself

Abstract

backgroundHelicobacter (H.) pylori is the major risk factor of gastric cancer (GC). We aimed to estimate the population attributable fraction (PAF) of GC and the number of new GC cases and deaths for GC attributable to H. pylori in different countries worldwide in 2022.

methodsThe PAF was estimated using country-specific pooled prevalence of H. pylori in the period 2000-2010 obtained through a systematic review and meta-analysis and a risk ratio of 5.9 for the association between H. pylori and GC. The absolute number of new GC cases and deaths for GC attributable to H. pylori was calculated using PAF and GC incidence and mortality reported by GLOBOCAN 2022.

resultsThe PAF of GC due to H. pylori was calculated for 27 countries. The average PAF was 69.7% ranging from 40.7% in Malaysia to 82.3% in South Africa. The PAF was > 70% in all countries in the analysis in Africa, East Mediterranean region and Latin America, apart from Mexico, and in some countries in Western Pacific region (China, Japan and Korea) and Europe (Poland, Spain and Albania). The largest number of GC cases and deaths for GC attributable to H. pylori was estimated in China (GC: 252,850, deaths:184,666) and Japan (GC: 92,166, deaths: 31,809).

conclusionsMore than two-thirds of new GC cases in the countries in the analysis were attributable to H. pylori in 2022. Our estimates may contribute to better investigate cost-effectiveness of H. pylori screening strategies for GC prevention in different countries worldwide.

Indexed as

Helicobacter InfectionsHelicobacter pyloriStomach NeoplasmsGlobal HealthHumansIncidencePrevalenceRisk FactorsEpidemiologyGastric cancerHelicobacter pylori

Identifiers

PMID41115989
PMCPMC12830462

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.