SynthesisBrain and behavior2025
The Role of Genetics in Stroke Risk and Outcome: A Review of Current Evidence.
Synthesis in Brain and behavior, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The Role of Genetics in Stroke Risk and Outcome: A Review of Current Evidence.Brain and behavior · 2025Pooled it
- Extracellular Vesicles in the Gut-Vascular-Brain Axis: A Missing Mechanistic Link Between IBD and Stroke Risk.Biomolecules · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeStroke affects over 15 million people annually, with genetic factors significantly influencing risk and recovery. Understanding the complex interplay of factors contributing to stroke is crucial for developing effective prevention and treatment strategies.
methodsThis review aims to synthesize current evidence regarding the genetic underpinnings of both stroke risk and outcome, encompassing ischemic stroke, hemorrhagic stroke, and specific stroke subtypes. Genetic factors uniquely explain variability in stroke risk and treatment response beyond traditional factors like hypertension. We examine the roles of common genetic variants identified through genome-wide association studies (GWAS), the influence of rare, high-impact mutations implicated in monogenic stroke disorders, and the contribution of epigenetic modifications to stroke vulnerability and recovery. Furthermore, we explore the impact of genes involved in key pathways such as coagulation, inflammation, lipid metabolism, and cerebrovascular structure and function. FINDING: This review highlights the growing body of evidence associating specific genetic variants with increased stroke susceptibility, altered stroke severity, and differential responses to treatment. These findings have the potential to refine risk stratification strategies, identify novel therapeutic targets, and personalize stroke management based on individual genetic profiles.
conclusionFuture research should focus on replicating findings across diverse populations, elucidating gene-environment interactions, and translating genetic discoveries into clinically actionable tools for stroke prevention and improved patient outcomes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.