Evidence map›Paper›PMID 41117048›Full record

ArticleLab on a chip2025

Endothelial-smooth muscle microgauges for modeling pulmonary arterial vasoregulation.

Aanya Sawhney, Raymond Piatt, Mitesh Rathod, Ryan N Stack, Chloe P Whitworth, William J Polacheck

Abstract read
In one paragraph

Article in Lab on a chip, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Aanya SawhneyLampe Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Chapel Hill and Raleigh, North Carolina, USA. polacheck@unc.edu.ORCID 0009-0002-3827-9580
Raymond PiattLampe Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Chapel Hill and Raleigh, North Carolina, USA. polacheck@unc.edu.
Mitesh RathodLampe Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Chapel Hill and Raleigh, North Carolina, USA. polacheck@unc.edu.
Ryan N StackLampe Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Chapel Hill and Raleigh, North Carolina, USA. polacheck@unc.edu.
Chloe P WhitworthDepartment of Genetics and Molecular Biology, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina, USA.
William J PolacheckLampe Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Chapel Hill and Raleigh, North Carolina, USA. polacheck@unc.edu.ORCID 0000-0003-2728-0746

Funding

Virology Research Program (Program 4)P30CA016086 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI JAMES E BEAR · 1985 to 2026
$201.5M
Integrative Approaches for the Study of the Fluidic Cellular MicroenvironmentR35GM142944 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI William J Polacheck · 2021 to 2026
$2.3M
American Heart Association 24PRE1192185National Science Foundation ECCS-2025064NCI NIH HHS P30 CA016086NIGMS NIH HHS R35 GM142944
6 · The paper itself

Abstract

Pulmonary arterial hypertension (PAH) is a devastating disease for which there is no cure. The pathogenesis of PAH involves endothelial dysfunction and dysregulation of vascular tone, resulting in progressively narrowing pulmonary arteries that increase hemodynamic resistance and blood pressure. The development of effective therapeutics for PAH is hindered by limitations to animal models and a lack of humanized

Indexed as

Endothelial CellsMuscle, Smooth, VascularMyocytes, Smooth MusclePulmonary ArteryCells, CulturedHumansVasodilation

Identifiers

PMID41117048
PMCPMC12538385

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.