Evidence map›Paper›PMID 41117088›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

Engineered Multifunctional Hydrogel Delivering Novel CBX7 Inhibitor Modulates Cuproptosis Via Liquid-Liquid Phase Separation to Restore Cardiac Function in Aged Myocardial Infarction.

Jun Liu, Peng Qu, Jiao Shi, Tingting Liang, Yao Gu, Xue Li, Cui Ma, Danyang Zhao, Feila Liu, Qi Liang and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Jun LiuDepartment of Clinical Laboratory, Affiliated Hospital of North Sichuan Medical College, Nanchong, 637000, China.
Peng QuDepartment of Clinical Laboratory, Affiliated Hospital of North Sichuan Medical College, Nanchong, 637000, China.
Jiao ShiDepartment of Clinical Laboratory, Affiliated Hospital of North Sichuan Medical College, Nanchong, 637000, China.
Tingting LiangInstitute of Cardiovascular Diseases & Department of Cardiology, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, 610072, China.
Yao GuDepartment of Clinical Laboratory, Affiliated Hospital of North Sichuan Medical College, Nanchong, 637000, China.
Xue LiDepartment of Clinical Laboratory, Affiliated Hospital of North Sichuan Medical College, Nanchong, 637000, China.
Cui MaDepartment of Mathematics, Army Medical University, Chongqing, 400038, China.
Danyang ZhaoDepartment of Anesthesiology, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, 610072, China.
Feila LiuSchool of Pharmacy and Bioengineering, Chongqing University of Technology, Chongqing, 400050, China.
Qi LiangDepartment of Clinical Laboratory, Affiliated Hospital of North Sichuan Medical College, Nanchong, 637000, China.
Panke ChengInstitute of Cardiovascular Diseases & Department of Cardiology, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, 610072, China.ORCID https://orcid.org/0000-0002-1900-8358
Qian LeiDepartment of Anesthesiology, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, 610072, China.

Funding

Key Research and Development Project of Science and Technology of Sichuan Province 2022YFS0605National Natural Science Foundation of China 82470290Noncommunicable Chronic Diseases-National Science and Technology Major Project 2024ZD0527205Sichuan Cadre Health Research Project ZH2025-202Sichuan Provincial Science and Technology Program 2023YFS0036
6 · The paper itself

Abstract

Cardiac repair after myocardial ischemia-reperfusion (MIR) declines with aging. This study shows that Chromobox 7 (CBX7) acts in an age-dependent manner, in young hearts, it promotes cardiomyocyte proliferation, whereas in aged hearts, CBX7 forms liquid-liquid phase separation (LLPS) with ATP7A, trapping ATP7A intracellularly, reducing membrane trafficking and copper efflux, and triggering cuproptosis. High-throughput screening identifies δ-Amyrenone (δAe) as a selective CBX7 inhibitor that disrupts CBX7-ATP7A LLPS, restores ATP7A trafficking and copper efflux, and improves cardiac function while reducing fibrosis and arrhythmias. Single-cell RNA-seq shows MIR-induced cuproptosis-related loss is concentrated in NR4A3 positive cardiomyocytes and RGCC positive capillary endothelial cells in aged hearts. To enhance delivery, this study engineered a multifunctional conductive hydrogel with antioxidant, pro-angiogenic, immunomodulatory, O

Indexed as

HydrogelsMyocardial InfarctionAgingAnimalsDisease Models, AnimalMaleMiceMice, Inbred C57BLMyocytes, CardiacPhase SeparationHydrogelsCBX7cuproptosishydrogelliquid–liquid phase separationδ‐Amyrenone

Identifiers

PMID41117088
PMCPMC12767114

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.