Evidence map›Paper›PMID 41117375›Full record

ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2025

The association of common infectious exposures with cognitive performance in community-dwelling older adults.

Jackson A Roberts, Mitchell S V Elkind, Minghua Liu, Stephanie Assuras, Bonnie E Levin, Vanessa Guzman, Tatjana Rundek, Jose Gutierrez

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. The association of common infectious exposures with cognitive performance in community-dwelling older adults.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jackson A RobertsDepartment of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York, USA.ORCID 0000-0003-2231-2454
Mitchell S V ElkindDepartment of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York, USA.
Minghua LiuDepartment of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York, USA.
Stephanie AssurasDepartment of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York, USA.
Bonnie E LevinDepartment of Neurology, Evelyn F. McKnight Brain Institute, Miller School of Medicine, Miami, Florida, USA.
Vanessa GuzmanDepartment of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York, USA.
Tatjana RundekDepartment of Neurology, Evelyn F. McKnight Brain Institute, Miller School of Medicine, Miami, Florida, USA.
Jose GutierrezDepartment of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York, USA.

Funding

Genetic Contribution to Brain Arterial Dilatation and its Role in Cognition and dementiaR01AG057709 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GUTIERREZ, JOSE · 2018 to 2022
$4.6M
ARCH PLAQUES AND STROKE IN AN ETHNICALLY MIXED COMMUNITYR01NS036286 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI DI TULLIO, MARCO R · 1997 to 2009
$3.4M
Accelerated non-atherosclerotic brain arterial aging relationship to Alzheimer's diseaseR01AG066162 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GUTIERREZ, JOSE · 2019 to 2023
$3.1M
NIA NIH HHS R01 AG057709NIA NIH HHS R01 AG066162NIH HHS R01 AG057709NIH HHS R01 AG066162NIH HHS R01 NS36286NINDS NIH HHS R01 NS036286
6 · The paper itself

Abstract

introductionThe Northern Manhattan Study (NOMAS) previously identified that a combined infectious disease exposure index correlates with impaired cognitive performance in older adults.

methodsWe extended these findings by examining the association of serological titers of five common infectious diseases (herpes simplex virus [HSV] 1 and 2, cytomegalovirus [CMV], Chlamydia pneumoniae, and Helicobacter Pylori) with domain-specific cognitive performance and incident cognitive impairment and dementia in 593 community-dwelling older adults. We performed confounder-adjusted mixed linear regression between infectious serologies and longitudinal cognitive performance.

resultsCMV and HSV-2 serologies were associated with impaired executive function, whereas C. pneumoniae serology was associated with impaired performance on language testing. In univariate Cox proportional hazard models, CMV serologies were associated with incident cognitive impairment and dementia. DISCUSSION: CMV seropositivity may accelerate domain-specific cognitive worsening and could confer increased risk for cognitive impairment and dementia, warranting further evaluation in observational and experimental datasets. HIGHLIGHTS: Infectious exposures may contribute to neurodegeneration and risk of cognitive impairment. Cytomegalovirus (CMV) and herpes simplex virus 2 exposure were associated with impaired executive function. Chlamydia pneumoniae was associated with decreased performance on language testing. CMV may be associated with incident cognitive impairment and dementia.

Indexed as

CognitionCognitive DysfunctionDementiaAgedAged, 80 and overChlamydophila pneumoniaeCytomegalovirusCytomegalovirus InfectionsFemaleHelicobacter pyloriHumansIndependent LivingLongitudinal StudiesMaleNeuropsychological TestsAlzheimer's diseasecognitive impairmentcytomegalovirusdementiaHerpesviridaememoryneuropsychological testing

Identifiers

PMID41117375
PMCPMC12538643

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.