ReviewNutritional neuroscience2026
The impact of nutritional and exercise interventions on Alzheimer's disease pathophysiology via modulation of the microbiota-gut-brain-axis.
Review in Nutritional neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Exploring the molecular mechanisms by which exercise improves cognitive impairment in Parkinson's disease based on the brain-gut microbiota axis: bibliometrics and visualization analysis.Frontiers in microbiology · 2026Pooled it
- The Neuroprotective Role of Exercise in Alzheimer's Disease: An Integrative Review of Animal and Human Studies.Neurology international · 2026Review
- Exercise-based modulation of the gut-brain axis: a new direction for neurorehabilitation in Alzheimer's disease.Frontiers in aging neuroscience · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
objectivesThe gut microbiota refers to a complex and essential ecosystem comprised of over 100 trillion microbial cells. The microbiota, the gut, and the brain together create an association which is vital to host health, 'the microbiota-gut-brain axis,' and coordinate the gut with the central nervous system to modify cognitive function and brain immune homeostasis. This bidirectional talk between the gut and brain operates via the immune system, the enteric nervous system, as well as various microbial metabolites, including short-chain fatty acids (SCFAs), and proteins. Recent studies have suggested an important role for the gut microbiota in many neurodegenerative diseases, including Alzheimer's disease (AD). The neuropathological hallmarks of Alzheimer's disease consist of beta-amyloid plaques, tau hyperphosphorylation, neurofibrillary tangles, glial activation, and neuronal and synaptic loss.
methodsIn this narrative review, we summarize the major outcomes of recent studies investigating the impacts of nutrition interventions, exercise interventions, and combined lifestyle (exercise + nutrition) interventions on Alzheimer's pathophysiology in animal models.
resultsCollectively, the interventions reviewed here all achieved significantly improved measures of cognitive function, beta-amyloid plaque aggregation and glial responses in the rodents, and led to the alterations in gut microbial composition, changes in bacterial metabolites, neuroinflammation, synaptic plasticity, and blood-brain barrier integrity. DISCUSSION: Understanding the role of the microbiota-gut-brain axis pathways during lifestyle interventions discussed in this study may assist in providing novel targets to delay the onset and progression of AD or alleviate extant AD pathophysiology, and may promote a reduction in the prevalence of AD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.