ArticleThe Journal of international medical research2025
Association of sirtuin 1 rs10997868 and rs730821 polymorphisms with sirtuin 1 and hydroxy-2'-deoxyguanosine levels in healthy smokers: A case-control study.
Article in The Journal of international medical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
ObjectivesThis case-control study explored the association of sirtuin 1 polymorphisms (rs10997868 and rs730821) with metabolic parameters, smoking duration, sirtuin 1 levels, and the oxidative stress biomarker 8-hydroxy-2'-deoxyguanosine in healthy smokers in Saudi Arabia.MethodsGenomic DNA was isolated from peripheral blood samples, and rs10997868 and rs730821 polymorphism genotyping was performed for 43 healthy smokers and 33 healthy controls using real-time polymerase chain reaction. Plasma sirtuin 1 and 8-hydroxy-2'-deoxyguanosine levels were measured using enzyme-linked immunosorbent assay.ResultsSirtuin 1 levels were significantly higher in healthy smokers than in controls, while 8-hydroxy-2'-deoxyguanosine levels were not significantly lower in healthy smokers. There was no significant association of sirtuin 1 protein expression and 8-hydroxy-2'-deoxyguanosine levels with rs10997868 and rs730821. Our findings showed a significant association between smoking duration and rs10997868 single nucleotide polymorphism, which was highest in those with the C/C genotype and lowest in those with the A/C genotype (
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