Evidence map›Paper›PMID 41117982›Full record

ArticleEuropean journal of nuclear medicine and molecular imaging2026

Peptide receptor radionuclide therapy alone or in combination with temozolomide plus/minus capecitabine in [

Gianpaolo di Santo, Giulia Santo, Lukas Wirth, Ariane Kronthaler, Günther Gastl, Angela Djanani, Irene J Virgolini

Abstract read
In one paragraph

Article in European journal of nuclear medicine and molecular imaging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Gianpaolo di SantoDepartment of Nuclear Medicine, Medical University of Innsbruck, Anichstrasse 35, Innsbruck, 6020, Austria.
Giulia SantoDepartment of Nuclear Medicine, Medical University of Innsbruck, Anichstrasse 35, Innsbruck, 6020, Austria.ORCID 0000-0001-6565-0686
Lukas WirthDepartment of Nuclear Medicine, Medical University of Innsbruck, Anichstrasse 35, Innsbruck, 6020, Austria.
Ariane KronthalerDepartment of Nuclear Medicine, Medical University of Innsbruck, Anichstrasse 35, Innsbruck, 6020, Austria.
Günther GastlDepartment of Internal Medicine V, Medical University of Innsbruck, Innsbruck, Austria.
Angela DjananiDepartment of Internal Medicine I, Gastroenterology, Hepatology, Endocrinology & Metabolism, Medical University Innsbruck, Innsbruck, Austria.
Irene J VirgoliniDepartment of Nuclear Medicine, Medical University of Innsbruck, Anichstrasse 35, Innsbruck, 6020, Austria. irene.virgolini@i-med.ac.at.ORCID 0000-0001-7097-6170

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundRecent data demonstrate that one possibility for increasing Peptide Receptor Radionuclide Therapy (PRRT) results lies in the combination of PRRT with chemotherapy. This study aimed to evaluate response and outcome in [

methodsAll mNET patients presented with [

resultsA total of 24 patients were included in the final analysis. Group 1 received PRRT with [

conclusionOur results show PRRT combined with CAPTEM as the most promising regimen, achieving higher response rates in [¹⁸F]FDG-positive mNETs compared with PRRT alone or PRRT plus TEM. Further studies are required to confirm its added value in terms of survival outcomes. No increased toxicity seems to be associated with combination therapy compared to PRRT alone.

Indexed as

CapecitabineFluorodeoxyglucose F18Neuroendocrine TumorsReceptors, PeptideAdultAgedFemaleHumansMaleMiddle AgedNeoplasm MetastasisOctreotideOrganometallic CompoundsPositron Emission Tomography Computed TomographyRetrospective StudiesTemozolomideCapecitabineFluorodeoxyglucose F18lutetium Lu 177 dotatateOctreotideOrganometallic CompoundsReceptors, PeptideTemozolomide[18F]FDGCAPTEMNeuroendocrine tumorsPeptide receptor radionuclide therapy

Identifiers

PMID41117982
PMCPMC12860813

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.