ArticleJournal of cancer survivorship : research and practice2025
Weight change and diabetes risk following breast cancer: a nationwide cohort study.
Article in Journal of cancer survivorship : research and practice, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundBreast cancer survivors (BCS) are at an increased risk of diabetes and frequently experience weight gain post-diagnosis. This study examined the association between post-diagnostic weight changes and diabetes risk in BCS.
methods40,850 BCS without a history of diabetes were identified. Changes in obesity status (body mass index ≥ 25 kg/m
resultsDuring a mean follow-up of 4.6 years, transitioning from non-obese to obese was associated with a 45% increased diabetes risk (aHR 1.45, 95% CI 1.16-1.82). Persistent obesity was associated with an 87% increased diabetes risk (aHR 1.87, 95% CI 1.64-2.15). The strength of the association decreased in individuals who reverted from obese to non-obese (aHR 1.42, 95% CI 1.18-1.71). Substantial weight loss (> 10%) after diagnosis was associated with a 45% decreased risk of diabetes (aHR 0.55, 95% CI 0.43-0.70). In contrast, moderate weight gain (5-10%) was associated with an 18% increased risk (aHR 1.18, 95% CI 1.02-1.38).
conclusionsOur findings suggest that transitioning to or maintaining an obese status post-diagnosis is associated with an increased diabetes risk, while substantial weight loss post-diagnosis is associated with a notable decrease in diabetes risk. Addressing obesity could significantly decrease the incidence of new-onset diabetes after breast cancer development. IMPLICATIONS FOR CANCER SURVIVORS: Breast cancer survivors are advised to maintain a healthy body weight after their diagnosis to help reduce the risk of diabetes.
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