ArticleJournal of cosmetic dermatology2025
New Insights Into Advanced Glycation End Products Induced Melanogenesis and Intervention Strategies.
Article in Journal of cosmetic dermatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- New Insights Into Advanced Glycation End Products Induced Melanogenesis and Intervention Strategies.Journal of cosmetic dermatology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
backgroundSkin hyperpigmentation refers to areas of skin that become darker than the surrounding skin due to an increase in melanin production, which greatly impacts skin esthetics. UV exposure, intrinsic hormonal changes, or injury are the general causes of hyperpigmentation. Recently, studies indicated that advanced glycation end products (AGEs) contribute to hyperpigmentation. However, detailed mechanisms involved in this process as well as therapeutic solutions are yet to be explored.
aimsThis study aimed to investigate the underlying mechanisms as well as intervention strategies targeting AGEs-induced melanogenesis.
methodsThe study exposed skin cells and 3D epidermal models to AGEs and measured melanin production and tyrosinase activity. Dimethoxytolyl propylresorcinol (DP), niacinamide, and green tea extract were tested for their ability to inhibit AGEs-induced melanogenesis or related cytokines. The AGEs breaking efficacy of DP was assessed on glycated lysozyme by mass spectrometry, as well as on glycated skin cells and 3D full-thickness skin models. RESULTS AND
conclusionsExposure to AGEs stimulates tyrosinase activity and melanin production in melanocytes and 3D melanocyte-containing epidermal skin models. AGEs upregulate IL-33 expression in fibroblasts via NLRP1/Caspase1 activation. DP was discovered to be an effective AGEs crosslink breaker and also capable of inhibiting AGEs induced melanin production in skin models. Moreover, niacinamide and green tea extract effectively inhibit IL-18/IL-33 secretion stimulated by AGEs. Those 3 components work collectively to target different stages of AGEs induced melanogenesis in skin and appear to be a potent intervention strategy to treat skin hyperpigmentation and sallowness issues during the aging process.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.