ArticleScientific reports2025
B-cell epitope mapping of Orthoflavivirus zikaense in mother-newborn immune interaction reveals postnatal immune signatures.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
Abstract
In 2015, the Orthoflavivirus zikaense (ZIKV) outbreak in Brazil caught the attention of the global community as a public health emergency. ZIKV, an Orthoflavivirus transmitted by Aedes mosquitoes, initially identified in 1947, has evolved from a historically inconspicuous pathogen to a significant public health concern. Beyond mild symptoms resembling Dengue fever, severe conditions such as microcephaly and Guillain-Barré syndrome have been linked to the infection caused by ZIKV. In regions already burdened by arboviruses such as Orthoflavivirus denguei (DENV), the co-circulation of these pathogens has created challenges for diagnosis and clinical management. Studies highlighted the simultaneous circulation of DENV and ZIKV, often following one another in time and space. The Asian genotype of ZIKV have shown evidence of codon usage adaptations enhancing replication efficiency in human hosts, contributing to the virus's rapid global spread. Furthermore, the arbovirus outbreaks in Brazil were characterized by a wave-like pattern, where viral transmission appears to follow a coordinated sequence. Despite the critical public health implications of ZIKV, studies focusing on the detailed epitope mapping of ZIKV proteins remain scarce. This study aims to investigate the epitope mapping patterns of ZIKV polyprotein in IgG ZIKV-positive individuals, correlating with newborns' maternal immune interaction by SPOT-synthesis. Notably, protein C, E, NS1, and NS5 regions exhibited high membrane reactivity and epitope recognition patterns. Additionally, C, E, NS1, and NS5 proteins displayed immunogenic potential with differential responses in newborns. The study enhances the understanding of ZIKV humoral immune response and suggests further investigations for epitope validation and potential vaccine development.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.