ArticleScientific reports2025
Investigation of multifaceted wound healing effect of exopolysaccharide (EPS) produced from probiotic strain Lactiplantibacillus plantarum GD2 as in vitro and in ovo.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Probiotics and Extracellular Vesicles as Redox Modulators in Wound Healing: From Microbial Therapeutics to Engineered Nanotherapeutic Strategies.Antioxidants (Basel, Switzerland) · 2026Review
- Microbiotherapy: an emerging adjunct for burn wound healing.Frontiers in cellular and infection microbiology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Skin wounds may threaten quality of life and cause serious complications. This study aimed to investigate the effects of lyophilized exopolysaccharide (L-EPS) obtained from the probiotic strain Lactiplantibacillus plantarum GD2 on various stages of wound healing. The results revealed that L-EPS accelerated in vitro wound healing and increased COL1A1 in L929 cells. L-EPS affected the TGF-β1/Smad signaling pathway by increasing the expression of the TGF-β1, Smad2, Smad3, and Smad4 genes. L-EPS also exerted anti-inflammatory effects by reducing the gene expression of IL-1β, IL-6 and iNOS in TNF-α-induced fibroblasts. Additionally, L-EPS demonstrated fibroproliferative effect on both healthy and TNF-α-induced fibroblasts. Furthermore, L-EPS was found to have a proangiogenic effect in ovo chorioallantoic membrane (CAM) model. This study presents the first-ever characterization of the multifaceted effects of L-EPS derived from the probiotic strain L. plantarum GD2 on wound healing. Our findings highlight the potential of L-EPS as effective agent for wound healing and suggest possible application in the development of wound healing biomaterials. By elucidating the mechanism of action of L-EPS in wound healing, this research may provide new perspectives for advanced treatment strategies in the field of wound care.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.