ArticleJournal of translational medicine2025
Platelet-rich plasma alleviates endoplasmic reticulum stress via the IGF1R-PI3K-AKT pathway in temporomandibular joint osteoarthritis: an in vivo clinical trial.
Article in Journal of translational medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Regenerative Medicine Approaches to Craniofacial and Corneal Neuropathic Pain.Pharmaceuticals (Basel, Switzerland) · 2026Review
- Intelligent GelMA microspheres co-loaded with BMSCs and Kartogenin for spatiotemporally controlled release and immunomodulatory regeneration of temporomandibular joint osteoarthritis.Frontiers in immunology · 2026Article
- Evolution and mechanistic insights of platelet-derived products in temporomandibular joint regeneration.Frontiers in cell and developmental biology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
backgroundTemporomandibular joint osteoarthritis (TMJ-OA) is a subtype of temporomandibular joint disorder characterised by synovial inflammation and cartilage degradation. Endoplasmic reticulum stress (ERS) plays a critical role in osteoarthritis pathophysiology. This study aimed to investigate the protective effects of platelet-rich plasma (PRP) on condylar chondrocytes, focusing on its potential to alleviate ERS and inhibit apoptosis, and evaluate the efficacy of PRP as a therapeutic strategy for TMJ-OA.
methodsWe conducted in vivo and in vitro experiments using transcriptome sequencing, RT-qPCR, and western blotting to examine the effects of PRP on the condylar chondrocytes. This study focused on ERS regulation and the IGF1R/PI3K/AKT signalling pathway. A clinical trial was performed to compare the therapeutic benefits of single and multiple PRP injections in patients (n = 32) with TMJ-OA.
resultsPRP effectively repaired cartilage damage in TMJ-OA by reducing ERS and inhibiting apoptosis via the IGF1R/PI3K/AKT axis. Both animal models and clinical trials have demonstrated that multiple PRP injections provide superior outcomes in condylar cartilage repair, pain relief, and functional improvement compared with those with a single injection.
conclusionsPRP alleviates condylar chondrocyte ERS and inhibits apoptosis, contributing to the repair of cartilage damage in TMJ-OA. Multiple PRP injections are more effective than a single injection, supporting their use as promising therapeutic strategies for TMJ-OA management.
trial registrationChinese Clinical Trial Registry (registration ID ChiCTR1900023013).
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.