ReviewFEBS letters2026
Spatiotemporal and quantitative analyses of phosphoinositides - fluorescent probe-and mass spectrometry-based approaches.
Review in FEBS letters, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Phosphoinositides and inositol phosphates-functions and cellular dynamics.FEBS letters · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Comprehensive understanding of phosphoinositide signaling requires both spatiotemporal visualization and precise quantitative analysis of individual lipid species. Phosphoinositides, a family of phosphorylated derivatives of phosphatidylinositol (PI), are structurally diverse lipid messengers that orchestrate a wide range of cellular functions, including membrane trafficking, cytoskeletal dynamics, and signal transduction. Due to their dynamic metabolism and compartment-specific localization, their analysis demands complementary strategies that integrate live-cell imaging with molecular quantification. In this review, we first summarize the development and application of fluorescence-based probes designed to monitor the distribution and dynamics of phosphoinositides in living cells, highlighting their specificity, targeting mechanisms, and limitations. We then provide an overview of recent advances in mass spectrometry-based methodologies that enable high-sensitivity, isomer-resolved quantification of phosphoinositides in biological specimens, including improvements in lipid extraction, derivatization, and chromatographic separation. Together, these dual approaches offer synergistic insights into the biochemical and cellular regulation of phosphoinositide signaling.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.