ArticleInternational journal of endocrinology2025
Neu-P11 Improves Type 2 Diabetes Mellitus Immune Function by Inhibiting the Hippo Signaling Pathway.
Article in International journal of endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: Melatonin (Mel) plays a significant role in maintaining bodily homeostasis and regulating insulin resistance (IR) associated with Type 2 diabetes mellitus (T2DM). Neu-P11 is a novel Mel receptor agonist that has been reported to play a critical role in immune function in T2DM. This study aims to investigate the impact of Neu-P11 on the immune function in individuals with T2DM and its potential regulatory pathways. Material and Methods: After inducing IR in 3T3-L1 cells, the study examined the impact of piromelatine (Neu-P11) and XMU-MP-1 (a Hippo pathway inhibitor) on the levels of Hippo pathway proteins, cell viability, extracellular glucose, and GLUT4 expression. After establishing T2DM in rats by a high-fat diet and streptomycin, the effects of Neu-P11 and XMU-MP-1 on glucose metabolism and serum levels of insulin, IgA, IgG, and IgM were investigated. Primary splenocytes isolated from experimental rats were analyzed for the number of immune cells and reactive oxygen species (ROS). Results: In our study, Mel, Neu-P11, and XMU-MP-1 reduced the levels of phospho-MST1/2, phospho-LATS1/LATS1, phospho-YAP/YAP, and phospho-TAZ/TAZ in the Hippo pathway and enhanced cell viability and glucose uptake capability. This effect was more evident in the Neu-P11+XMU-MP-1 group. After treatment with Mel, Neu-P11, and XMU-MP-1, respectively, T2DM rats showed slower weight gain and a decreased spleen index, suppressed splenic ROS, downregulated phosphorylated Hippo pathway proteins, decreased IgA, and increased IgG and IgM, with improved glucose and insulin tolerance. Mel, Neu-P11, and XMU-MP-1 increased the immune cell number (CD3+, CD16+, and CD19+) in T2DM rats. Notably, co-treatment of Neu-P11 and XMU-MP-1 demonstrated superior restoration across all parameters, indicating the efficacy of combinatorial targeting. Conclusion: Neu-P11 improves immune function and increases insulin sensitivity in T2DM by inhibiting the Hippo signaling pathway, offering a novel therapeutic avenue for T2DM.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.