Evidence map›Paper›PMID 41122324›Full record

ArticleActa naturae

The Generation and Characterization of a Mouse Embryonic Stem Cell Line with Psmb9 Immunoproteasome Gene Knockout.

D V Kriger, U I Podenkova, A A Kuzmin, N D Aksenov, A V Kropacheva, A S Zinovyeva, A V Selenina, A N Tomilin, A S Tsimokha

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta naturae. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

D V KrigerInstitute of Cytology, Russian Academy of Sciences, St-Petersburg, 194064 Russia.
U I PodenkovaInstitute of Cytology, Russian Academy of Sciences, St-Petersburg, 194064 Russia.
A A KuzminInstitute of Cytology, Russian Academy of Sciences, St-Petersburg, 194064 Russia.
N D AksenovInstitute of Cytology, Russian Academy of Sciences, St-Petersburg, 194064 Russia.
A V KropachevaInstitute of Cytology, Russian Academy of Sciences, St-Petersburg, 194064 Russia.
A S ZinovyevaInstitute of Cytology, Russian Academy of Sciences, St-Petersburg, 194064 Russia.
A V SeleninaInstitute of Cytology, Russian Academy of Sciences, St-Petersburg, 194064 Russia.
A N TomilinInstitute of Cytology, Russian Academy of Sciences, St-Petersburg, 194064 Russia.
A S TsimokhaInstitute of Cytology, Russian Academy of Sciences, St-Petersburg, 194064 Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Immunoproteasomes, a unique type of proteasome complex, play a critical role in antigen presentation and cellular homeostasis. Unlike the constitutive 20S proteasome, the catalytic subunits β1, β2, and β5 in the immunoproteasome are replaced by inducible isoforms: β1i (LMP2), β2i (MECL-1), and β5i (LMP7). The expression of the genes encoding these subunits (Psmb9, Psmb10, and Psmb8) is activated by cytokines, primarily interferon-γ (IFNγ). Although it has been demonstrated more and more convincingly that immunoproteasomes are expressed in embryonic stem cells (ESCs), their involvement in maintaining pluripotency, promoting self-renewal, and regulating differentiation processes remains unexplored. This study implemented CRISPR/Cas9 technology to generate a

Indexed as

differentiationimmunoproteasomeLmp2mouse ESCsPsmb9

Identifiers

PMID41122324
PMCPMC12536984

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.