Evidence map›Paper›PMID 41122497›Full record

ArticleCanadian respiratory journal2025

Notoginsenoside R1 Improved Hypoxic Pulmonary Hypertension by Inhibiting Glycolysis-Mediated Pulmonary Arterial Vascular Remodeling.

Xiaowei Gong, Yanling Sheng, Gaijun Zhang, Shiwei Kang, Xin Liu, Yuming Wang, Tao Zhang, Hanzhou Li, Huan Pei, Yadong Yuan and 2 more

Abstract read
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In one paragraph

Article in Canadian respiratory journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Xiaowei GongDepartment of Respiratory Medicine, The Second Hospital of Hebei Medical University, Shijiazhuang 050000, China.
Yanling ShengDepartment of Respiratory and Critical Care Medicine, Huabei Petroleum Administration Bureau General Hospital, Cangzhou 062550, China.
Gaijun ZhangFirst School of Clinical Medicine, Yunnan University of Chinese Medicine, Kunming 650500, China.
Shiwei KangDepartment of Respiratory Medicine, The Second Hospital of Hebei Medical University, Shijiazhuang 050000, China.
Xin LiuDepartment of Respiratory Medicine, The Second Hospital of Hebei Medical University, Shijiazhuang 050000, China.
Yuming WangSchool of Integrative Chinese and Western Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China.
Tao ZhangDepartment of Respiratory Medicine, The Second Hospital of Hebei Medical University, Shijiazhuang 050000, China.
Hanzhou LiSchool of Integrative Chinese and Western Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China.
Huan PeiFirst School of Clinical Medicine, Yunnan University of Chinese Medicine, Kunming 650500, China.
Yadong YuanDepartment of Respiratory Medicine, The Second Hospital of Hebei Medical University, Shijiazhuang 050000, China.ORCID 0000-0002-1319-4743
Feitian MinFirst School of Clinical Medicine, Yunnan University of Chinese Medicine, Kunming 650500, China.ORCID 0000-0002-0053-5561
Huantian CuiFirst School of Clinical Medicine, Yunnan University of Chinese Medicine, Kunming 650500, China.ORCID 0000-0002-0820-5436

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hypoxic pulmonary hypertension (HPH) lacks effective treatments. The research is designed to examine the effectiveness of Notoginsenoside R1 (NGR1) in addressing HPH and to explore its molecular mechanisms. Under hypoxic conditions, we created a rat model of HPH and treated the animals with NGR1. We assessed the therapeutic effects of NGR1 on HPH through hemodynamic measurements and pulmonary artery vascular remodeling. We employed transcriptomic analysis to evaluate gene expression changes in HPH rats. We conducted untargeted metabolomics to examine how NGR1 influences the metabolic profile of HPH rats. NGR1 treatment significantly improved hemodynamic parameters and ameliorated pulmonary artery vascular remodeling in HPH rats. Transcriptomic analysis identified

Indexed as

GinsenosidesGlycolysisHypertension, PulmonaryHypoxiaPulmonary ArteryVascular RemodelingAnimalsDisease Models, AnimalMaleRatsRats, Sprague-DawleyGinsenosidesnotoginsenoside R1glycolysishypoxic pulmonary hypertensionNotoginsenoside R1transcriptomicsuntargeted metabolomics

Identifiers

PMID41122497
PMCPMC12537236

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.