SynthesisFrontiers in nutrition2025
The efficacy of dietary therapies in modulating inflammatory biomarkers, clinical remission and quality of life in patients with inflammatory bowel disease: a network meta-analysis of 15 interventions.
Synthesis in Frontiers in nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Comparative efficacy of dietary interventions and enteral nutrition in adults with ulcerative colitis: a network meta-analysis.Frontiers in nutrition · 2026Pooled it
- Plant-derived bioactives, the gut-brain axis, and neurodegenerative diseases: mechanistic roles of diet-microbiota interactions.Frontiers in neuroscience · 2026Review
- Anti-inflammatory dietary interventions in inflammatory bowel disease: current insights and future perspectives.Frontiers in nutrition · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Scientific dietary interventions are useful methods for managing inflammatory bowel disease. It is unclear which dietary pattern is most effective in improving IBD symptoms. Therefore, this network meta-analysis compared the impact of popular dietary patterns on patients with established IBD. Methods: A computerized search of randomized controlled trials on the use of dietary therapy to improve inflammatory bowel disease in both Chinese and English databases. The primary outcome measures were CRP, ALB, IBDQ and MES. Stata 16.0 software was used for the network meta-analysis. Results: A total of 25 RCTs were ultimately included. The study included the following 15 treatments. The network meta-analysis revealed that, for reducing CRP levels, LFD + EN was significantly more effective than LRD [MD = -5.21 mg/L, 95% CI (-7.05, -3.36)], RD [MD = -4.63 mg/L, 95% CI (-6.22, -3.03)], CDED + EN [MD = -4.48 mg/L, 95% CI (-7.45, -1.51)], LFD [MD = -4.47 mg/L, 95% CI (-6.27, -2.67)], MD + LFD + EN [MD = -3.68 mg/L, 95% CI (-5.90, -1.45)] and EN [MD = -1.26 mg/L, 95% CI (-2.29, -0.22)]. Conversely, LFD + EN was also superior in increasing ALB levels when compared to EN [MD = 3.64 g/L, 95% CI (0.71, 6.57)], LFD [MD = 6.35 g/L, 95% CI (2.85, 9.84)], RD [MD = 6.40 g/L, 95% CI (3.25, 9.54)], LRD [MD = 6.34 g/L, 95% CI (2.83, 9.84)], MD [MD = 6.34 g/L, 95% CI (2.83, 9.84)], CDED + EN [MD = 8.40 g/L, 95% CI (4.18, 12.61)] and lgG-ED [MD = 8.73 g/L, 95% CI (4.34, 13.11)]. Regarding MES, lgG-ED [SMD = 1.07, 95% CI (0.64, 1.50)], LFD [SMD = 0.75, 95% CI (0.48, 1.03)], EN [SMD = 0.64, 95% CI (0.27, 1.01)] all demonstrated a significant reduction in scores compared to RD. No significant difference was found in IBDQ. Conclusion: For reducing systemic inflammation (CRP, ALB), LFD + EN was ranked as the most effective strategy. For improving quality of life (IBDQ), MD + LFD + EN showed the highest probability of being the best. For inducing endoscopic remission (MES), IgG-ED was ranked highest among the compared interventions. In the future, evidence-based dietary interventions could be used in clinical practice. Systematic review registration: https://www.crd.york.ac.uk/PROSPERO/view/CRD420251038185.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.