Evidence mapPaperPMID 41123752Full record

ReviewVeterinary research communications2025

Monoclonal antibodies in veterinary antiviral immunotherapy: technologies, applications and challenges.

Serkan Kökkaya, Ayşe Gençay Göksu, İbrahim Sözdutmaz, Muhammed Arif Toy, Engin Berber

Abstract readReview
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In one paragraph

Review in Veterinary research communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Serkan KökkayaFaculty of Veterinary Medicine, Department of Virology, Yozgat Bozok University, Yozgat, Türkiye.ORCID http://orcid.org/0000-0002-9504-4350
Ayşe Gençay GöksuFaculty of Veterinary Medicine, Department of Virology, Erciyes University, Kayseri, Türkiye.ORCID http://orcid.org/0000-0003-4422-8085
İbrahim SözdutmazFaculty of Veterinary Medicine, Department of Virology, Erciyes University, Kayseri, Türkiye.ORCID http://orcid.org/0000-0002-3712-7991
Muhammed Arif ToyFaculty of Veterinary Medicine, Department of Virology, Erciyes University, Kayseri, Türkiye.ORCID http://orcid.org/0009-0003-6294-121X
Engin BerberLerner Research Institute, Infection Biology, Cleveland Clinic, 9500 Euclid Ave, Cleveland, OH, 44195, USA. berbere3@ccf.org.ORCID http://orcid.org/0000-0003-0420-7714

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Monoclonal antibodies (mAbs) are highly specific immunoglobulins that bind viral antigens with high affinity, making them valuable tools for diagnosis and targeted antiviral therapy in veterinary medicine. While mAbs are widely used in human healthcare, their application in veterinary medicine is limited. Only a few licensed products are available for animal health, and most candidates are in experimental or pre-clinical stages. This review provides a comprehensive overview of neutralizing mAbs targeting veterinary viral pathogens, including significant advances in production technologies and associated challenges. These innovations aim to reduce immunogenicity, improve efficacy, and expand the range of treatable diseases in companion animals, livestock, and wildlife. Despite these advances, high production costs, logistical constraints, and viral escape through mutation remain significant challenges to clinical implementation. If technological progress is integrated with strategies for overcoming these limitations, antiviral mAbs have the potential to become essential components of veterinary medicine. Their incorporation into a One Health framework could also enhance preparedness for emerging and zoonotic viral threats.

Indexed as

Antibodies, MonoclonalAntiviral AgentsImmunotherapyVirus DiseasesAnimalsVeterinary MedicineAntibodies, MonoclonalAntiviral AgentsAntiviral therapyMonoclonal antibodyMonoclonal antibody therapyNeutralizing antibodyVeterinaryVirology

Identifiers

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.