Evidence map›Paper›PMID 41123758›Full record

ArticleJournal of molecular neuroscience : MN2025

LncRNA MYL2 Acts as a Sponge for miR-661 to Regulate Postoperative Cognitive Dysfunction.

Yiguo Xu, Xiaoyun He, Huijun Zhang, Xiuqing Wu, Hongbao Li, Fang Cao

Abstract read
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In one paragraph

Article in Journal of molecular neuroscience : MN, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yiguo XuAnesthesiology Department, The First Affiliated Hospital of Ningbo University, No. 59, Liuting Street, Ningbo, 315000, Zhejiang Province, China. xuyiguo66688@163.com.
Xiaoyun HeAnesthesiology Department, The First Affiliated Hospital of Ningbo University, No. 59, Liuting Street, Ningbo, 315000, Zhejiang Province, China.
Huijun ZhangAnesthesiology Department, The First Affiliated Hospital of Ningbo University, No. 59, Liuting Street, Ningbo, 315000, Zhejiang Province, China.
Xiuqing WuAnesthesiology Department, The First Affiliated Hospital of Ningbo University, No. 59, Liuting Street, Ningbo, 315000, Zhejiang Province, China.
Hongbao LiAnesthesiology Department, The First Affiliated Hospital of Ningbo University, No. 59, Liuting Street, Ningbo, 315000, Zhejiang Province, China.
Fang CaoAnesthesiology Department, The First Affiliated Hospital of Ningbo University, No. 59, Liuting Street, Ningbo, 315000, Zhejiang Province, China. cangcangnd3200@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Postoperative cognitive dysfunction (POCD) has a significant impact on the postoperative life ability of the elderly, and nearly 50% of the elderly are at risk globally, but the molecular mechanism of its pathogenesis is still unclear. The aim of this study was to discuss the expression of lncRNA MYL2 in older rats and its effects to provide possible targets for future treatment. A POCD model of aged rats was established by osteotomy and sevoflurane, cognitive function was measured by the water maze (MWM), and the concentrations of tumor necrosis factor (TNF)-α, interleukin (IL)-6, IL-1β, and oxidative stress-related factors in the hippocampal tissue of rats were detected by enzyme-linked immunosorbent assay. Luciferase reporter gene analysis was used to detect the target gene of the targeting relationship between MYL2 and miR-661. Cell viability and apoptosis rate were assessed using CCK-8 and flow cytometry. MYL2 was up-regulated by Sev treatment in the rat hippocampus. Overexpression of MYL2 prolonged the escape latency of rats, shortened the time spent in the target quadrant of rats, and reduced the number of platform crossings. At the same time, the concentrations of pro-inflammatory factors and markers of oxidative stress were increased. miR-661 is a miRNA targeting MYL2. miR-661 could reverse the exacerbation effect of MYL2 on POCD. MYL2 serves as a potential sponge of miR-661, and its up-regulation is linked to exacerbated neuroinflammation, oxidative damage, and cellular dysfunction in POCD.

Indexed as

Cognitive DysfunctionMicroRNAsPostoperative Cognitive ComplicationsRNA, Long NoncodingAnimalsHippocampusMaleOxidative StressRatsRats, Sprague-DawleyMicroRNAsRNA, Long NoncodingCognitive dysfunctionLncRNA MYL2miR-661NeuroinflammationSevoflurane

Identifiers

PMID41123758

What Socratic holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.