ArticleClinical rheumatology2025
Exploration of the mechanism of intestinal flora-mediated immune modulation in the pathogenesis of gout.
Article in Clinical rheumatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Bidirectional mediation between microbiota and immune system in Parkinson disease: A two-sample Mendelian randomization study.Medicine · 2026Article
- Global, regional, and national burden of bladder cancer from 1990 to 2021 with projections to 2050: insights from the global burden of disease study and Mendelian randomization analysis.Infectious agents and cancer · 2025Article
- Reply to: "Toward precision maternal care in systemic lupus erythematosus: Bridging data limitations and research gaps".Clinical rheumatology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
introductionAlthough the role of immune cells in the pathogenesis of gout has been extensively studied, their interactions with the gut microbiota and the potential mediating effects in disease progression remain insufficiently characterized.
methodThis study used pooled data from genome-wide association studies (GWAS) to analyze associations among 731 immune cell phenotypes, 473 gut microbiota traits, and gout. A two-step mediation analysis identified microbiota potentially mediating the immune-gout relationship. Causal inference was primarily conducted using inverse-variance weighting (IVW), with MR-Egger, simple mode, weighted median, and weighted mode methods used to ensure robustness. Sensitivity analyses further confirmed the reliability of the findings.
resultsEight immune cell phenotypes were significantly linked to gout-five protective and three risk-related. Twenty gut microbial taxa were also associated, including seven protective and thirteen risk-related. Mediation analysis identified five microbial taxa (three genera, two species) mediating immune cell effects on gout. For example, higher TD CD8br %CD8br cells reduced gout risk by lowering Microvirga abundance (β = - 0.0315, P = 0.045), mediating 26.5%. In contrast, increased CD127 expression on CD28.
conclusionsThis study reveals a potential causal link between immune cells and gut microbiota in gout and identifies key microbial taxa involved. The findings deepen our understanding of gout pathogenesis and provide a basis for new therapeutic approaches. Key Points • Employed the authoritative FinnGen R12 disease database. • Utilized the latest gut microbiota GWAS data covering 473 microbial features. • Proposed a novel "immune cells-gut microbiota-gout" causal pathway. • Integrated multi-omics approaches for systematic mediation analysis.
Indexed as
Identifiers
41123770What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.