ArticlePloS one2025
Association between dietary B vitamins intake and age-specific blood pressure: A cross-sectional study in American adults.
Article in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Choline, a nexus for neurocognitive nutrients: A narrative review.Nutrition research (New York, N.Y.) · 2026Review
- The Association of Arsenic Metabolism and Blood Pressure: A Cross-Sectional Analysis in the MesoAmerican Nephropathy Occupational Study (MANOS).Research square · 2026Article
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6 authors.
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Abstract
objectiveTo explore the relationship between B vitamins and blood pressure across distinct age groups.
methodsWe analyzed 3654 participants aged ≥20 years after excluding pregnant/lactating individuals and those with incomplete data. B-vitamin intake was calculated from two 24-hour dietary recalls and supplement surveys. Exposure variables included 7 kinds of B vitamins intake, while outcomes comprised hypertension prevalence, systolic and diastolic pressure. The covariates include basic demographics, lifestyle factors, chronic Comorbidities, and nutrient intake. Based on the cross-sectional study, the statistical analyses incorporated NHANES sampling weights. Weighted logistic regression evaluated hypertension association, while linear regression assessed systolic/diastolic pressure differences. RCS model explored nonlinear dose-response relationships.
resultsWeighted logistic regression and RCS model revealed age-specific and nonlinear characteristics in the b vitamin-blood pressure relationship. Vitamin B1 was negatively correlated with hypertension in ≥60 years old (Q4: Q1 OR (95%CI) =0.27 (0.08, 0.91)). Vitamin B2 was negatively correlated with hypertension in total population at Q4 (OR (95%CI) =0.39 (0.15, 0.99)), and in aged 40-59 years, OR (95%CI) =0.52 (0.33, 0.83). Choline was positively correlated with hypertension in the total population (OR (95%CI) =1.30 (1.08, 1.58)) but negatively correlated with ≥60 years old (OR (95%CI = 0.73 (0.56, 0.95)). Vitamin B12 shown positive associations with hypertension in the total population, 20-39 years old and ≥60 years old OR (95%CI) =1.39 (1.13, 1.71), 1.82 (1.23, 2.69), and 1.63 (1.04, 2.54), respectively. For diastolic pressure, vitamin B1, B2, niacin, B6, and folate displayed significant negative associations in the total population and ≥60 years old. Vitamin B2 was also negatively associated in 40-59 years old. Vitamin B12 exhibited a negative association with diastolic pressure in ≥60 years old. Weight RCS analysis revealed the linear or nonlinear relationships between specific B vitamins and hypertension and systolic/diastolic pressure, with age stratification improving the discernment of these associations.
conclusionsAssociations between B vitamins intake and hypertension/blood pressure exhibited age-dependent variations. Age-specific considerations are essential for optimizing B vitamins supplementation or restriction.
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