Evidence map›Paper›PMID 41124262›Full record

ArticleScience advances2025

Remolding laccase for whole-cell and in vivo modulation of dopamine signal.

Xiaoti Yang, Shilong Fan, Jing Liu, Shuli Chen, Wenjie Wu, Xiling Chen, Wenliang Ji, Shuxin Li, Yifei Xue, Xinjie Sun and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Xiaoti YangCollege of Chemistry, Beijing Normal University, Beijing 100875, China.ORCID 0000-0001-5656-0486
Shilong FanBeijing Advanced Innovation Center for Structural Biology, School of Life Sciences Tsinghua University, Beijing 100084, China.ORCID 0000-0001-9272-2438
Jing LiuCollege of Chemistry, Beijing Normal University, Beijing 100875, China.ORCID 0000-0001-5282-785X
Shuli ChenCollege of Chemistry, Beijing Normal University, Beijing 100875, China.ORCID 0009-0008-8520-0015
Wenjie WuBeijing National Laboratory for Molecular Sciences, Key Laboratory of Analytical Chemistry for Living Biosystems, Institute of Chemistry, Chinese Academy of Sciences (CAS), Beijing 100190, China.ORCID 0000-0002-4217-9024
Xiling ChenBeijing Advanced Innovation Center for Structural Biology, School of Life Sciences Tsinghua University, Beijing 100084, China.
Wenliang JiCollege of Chemistry, Beijing Normal University, Beijing 100875, China.ORCID 0009-0005-2138-0860
Shuxin LiCollege of Chemistry, Beijing Normal University, Beijing 100875, China.ORCID 0009-0009-5246-3107
Yifei XueCollege of Chemistry, Beijing Normal University, Beijing 100875, China.ORCID 0009-0004-4175-6936
Xinjie SunCollege of Chemistry, Beijing Normal University, Beijing 100875, China.ORCID 0009-0009-6302-6498
Ming WangBeijing National Laboratory for Molecular Sciences, Key Laboratory of Analytical Chemistry for Living Biosystems, Institute of Chemistry, Chinese Academy of Sciences (CAS), Beijing 100190, China.
Ji LiuBeijing National Laboratory for Molecular Sciences, Key Laboratory of Analytical Chemistry for Living Biosystems, Institute of Chemistry, Chinese Academy of Sciences (CAS), Beijing 100190, China.ORCID 0009-0000-4506-767X
Fei WuCollege of Chemistry, Beijing Normal University, Beijing 100875, China.ORCID 0000-0002-9366-2374
Ping YuBeijing National Laboratory for Molecular Sciences, Key Laboratory of Analytical Chemistry for Living Biosystems, Institute of Chemistry, Chinese Academy of Sciences (CAS), Beijing 100190, China.ORCID 0000-0002-6096-1933
Lanqun MaoCollege of Chemistry, Beijing Normal University, Beijing 100875, China.ORCID 0000-0001-8286-9321

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Biocatalytic regulation of dopamine signals paves an effective and biocompatible way to modulate dopaminergic functions and disorders. Here, we report the remolding of bacterial laccase, catalyzing conversions of dopamine and O

Indexed as

DopamineLaccaseSignal TransductionAnimalsBiocatalysisCatalytic DomainCopperHumansSubstrate SpecificityCopperDopamineLaccase

Identifiers

PMID41124262
PMCPMC12542965

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.