Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
24 authors.
Teresa Cardoso DelgadoLiver Disease Lab, Center for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), 48160 Derio, Bizkaia, Spain.ORCID 0000-0001-9204-581X
Celia Martín-CuevasTranslational Psychiatry, Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, 41013 Sevilla, Spain.ORCID 0000-0003-1074-3724
Ana C Sánchez HidalgoTranslational Psychiatry, Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, 41013 Sevilla, Spain.ORCID 0000-0001-5785-2990
Antonio Gil GómezClinical and Translational Research in Liver and Digestive Diseases-SeLiver Group, Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, 41013 Sevilla, Spain.ORCID 0000-0001-9622-1761
Claudia M Rejano GordilloLiver Disease Lab, Center for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), 48160 Derio, Bizkaia, Spain.ORCID 0000-0003-4586-5975
Jon LandaCellular Oncology Group, 20014 Biogipuzkoa Health Research Institute, San Sebastian-Donostia, Spain.ORCID 0000-0002-7644-7517
Rocío Gallego DuránClinical and Translational Research in Liver and Digestive Diseases-SeLiver Group, Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, 41013 Sevilla, Spain.
Naroa Goikoetxea-UsandizagaLiver Disease Lab, Center for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), 48160 Derio, Bizkaia, Spain.
Irene González-RecioLiver Disease Lab, Center for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), 48160 Derio, Bizkaia, Spain.
Clàudia Gil-PitarchLiver Disease Lab, Center for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), 48160 Derio, Bizkaia, Spain.ORCID 0000-0003-2220-0612
L Estefanía Zapata-PavasLiver Disease Lab, Center for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), 48160 Derio, Bizkaia, Spain.ORCID 0009-0003-3433-7699
Jon Ander Barrenechea-BarrenecheaLiver Disease Lab, Center for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), 48160 Derio, Bizkaia, Spain.ORCID 0009-0007-5972-6796
Carolina ConterLiver Disease Lab, Center for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), 48160 Derio, Bizkaia, Spain.ORCID 0000-0002-5999-8667
Luis Alfonso Martínez-CruzLiver Disease Lab, Center for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), 48160 Derio, Bizkaia, Spain.ORCID 0000-0002-5856-9377
Víctor D Ramos HerreroTranslational Psychiatry, Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, 41013 Sevilla, Spain.ORCID 0000-0002-6082-7320
Rubén NogueirasDepartment of Physiology, CIMUS, University of Santiago de Compostela, Instituto de Investigación Sanitaria, Santiago de Compostela, Spain; CIBER Fisiopatologia de la Obesidad y Nutrición (CIBERobn), Madrid, Spain; Galician Agency of Innovation (GAIN), Xunta de Galicia, 15782 Santiago de Compostela, Spain.ORCID 0000-0002-9976-9930
Mikel AzkargortaProteomics Platform, Center for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), 48160 Derio, Bizkaia, Spain.ORCID 0000-0001-9115-3202
Felix ElortzaProteomics Platform, Center for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), 48160 Derio, Bizkaia, Spain.ORCID 0000-0001-8839-5438
Verónica Moncho-AmorCellular Oncology Group, 20014 Biogipuzkoa Health Research Institute, San Sebastian-Donostia, Spain.
Javier CrespoSchool of Medicine, University of Cantabria, Clinical and Translational Research in Digestive Diseases, Valdecilla Research Institute (IDIVAL), 39011 Santander. MedicineAI, 28028 Madrid, Spain.ORCID 0000-0001-8248-0172
Ander MatheuIKERBASQUE, Basque Foundation for Science, Bilbao, Spain.
Manuel Romero GómezClinical and Translational Research in Liver and Digestive Diseases-SeLiver Group, Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, 41013 Sevilla, Spain.ORCID 0000-0001-8494-8947
Benedicto Crespo-FacorroTranslational Psychiatry, Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, 41013 Sevilla, Spain.ORCID 0000-0003-0033-7132
María Luz Martínez-ChantarLiver Disease Lab, Center for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), 48160 Derio, Bizkaia, Spain.ORCID 0000-0002-6446-9911
Funding
No grant is acknowledged in the PubMed record.
6 · The paper itself
Abstract
Metabolic dysfunction-associated steatotic liver disease (MASLD), a liver-centric condition, is associated with cognitive impairment and sensorimotor alterations. However, it remains unclear whether MASLD is sufficient to drive central nervous system deficits. Here, using diet-induced mouse models, we showed that MASLD was associated with alterations in social memory, sensorimotor processing, and hippocampal function, including decreased parvalbumin-positive interneurons, reduced dendritic spine density, and diminished dentate gyrus neurogenesis and neuronal differentiation. Then, we selectively modulated liver metabolism through
Indexed as
BrainFatty LiverLiverRNA, Small InterferingAnimalsBehavior, AnimalDisease Models, AnimalHippocampusMaleMiceNeurogenesisRNA, Small Interfering
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.
Metabolic dysfunction-associated steatotic liver disease alters brain function and behavior: Insights from liver-targeted siRNA therapy. · full record | Socratic