ArticleMemorias do Instituto Oswaldo Cruz2025
The impact of probiotic administration on experimental in vitro and in vivo infection by Trypanosoma cruzi.
Article in Memorias do Instituto Oswaldo Cruz, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- The activity of miltefosine combined with oral probiotics in a mouse model of cutaneous leishmaniasis.Memorias do Instituto Oswaldo Cruz · 2025Article
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6 authors.
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Abstract
backgroundChagas disease (CD) caused by Trypanosoma cruzi has limited therapy. Probiotics sustain healthy microbiota, playing roles in biological events.
objectivesOur aim was to determine the impact of probiotics on T. cruzi infection in vitro and in mouse acute experimental models.
methodsThe multi strain - PB8 and the Lactobacillus rhamnosus (LR) were orally administered [106-109 colony-forming units (CFU)] for seven days prior to mice infection followed for 14 daily administrations. Peritoneal mouse macrophages (PMM) were obtained from mice treated with 109 probiotics one day before collection and infected in vitro with or not benznidazole (BZ).
findingsLR and PB8 reduced by 44-87% and 23-16% the parasitaemia peak in male and female mice, respectively, but did not protect against mortality. Histopathology showed mild reduction in cardiac nests due to probiotics' administration. PB8 and LR suppressed the parasite infection of PMM by 24 and 26%, reaching 65 and 42% of declines, respectively when 3% thioglycolate was performed. PB8 increased BZ activity at 1 µM, reaching 40% of parasitism' declines compared to BZ alone (25%). No gender difference was noticed during probiotic in vivo administration. MAIN
conclusionsThe results point to the potential of a combined therapeutic approach for CD, using probiotics and BZ.
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