Evidence map›Paper›PMID 41125373›Full record

ArticleInternal medicine (Tokyo, Japan)2026

Early Recovery from Cryptogenic NORSE Following Repeated C-NORSE Score Assessment and Cyclophosphamide Treatment.

Ryotaro Okochi, Jun Sakai, Sho Shimohama, Kei Ishizuchi, Jin Nakahara, Takahiro Iizuka, Munenori Oyama

Abstract readCase Reports
In one paragraph

Article in Internal medicine (Tokyo, Japan), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ryotaro OkochiDepartment of Neurology, Keio University School of Medicine, Japan.
Jun SakaiDepartment of Neurology, Keio University School of Medicine, Japan.
Sho ShimohamaDepartment of Neurology, Keio University School of Medicine, Japan.
Kei IshizuchiDepartment of Neurology, Keio University School of Medicine, Japan.
Jin NakaharaDepartment of Neurology, Keio University School of Medicine, Japan.
Takahiro IizukaDepartment of Neurology, Kitasato University School of Medicine, Japan.
Munenori OyamaDepartment of Neurology, Keio University School of Medicine, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cryptogenic new-onset refractory status epilepticus (C-NORSE) is a rare, severe condition characterized by refractory status epilepticus without identifiable causes. It is often unresponsive to first-line immunotherapy. The C-NORSE score is a useful diagnostic tool, but in the early phase, when the score remains low and antibody test results are unavailable, it is difficult to initiate second-line immunotherapy, including cyclophosphamide. We report a 27-year-old man with C-NORSE who achieved early recovery and favorable outcome following administration of intravenous cyclophosphamide, despite a low C-NORSE score on admission, suggesting the importance of repeated assessment using the C-NORSE score and early administration of cyclophosphamide.

Indexed as

CyclophosphamideImmunosuppressive AgentsStatus EpilepticusAdultHumansMaleTreatment OutcomeCyclophosphamideImmunosuppressive Agentscase reportC-NORSE scorecryptogenic NORSEcyclophosphamideimmunotherapyrefractory status epilepticus

Identifiers

PMID41125373
PMCPMC13294485

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.