Evidence map›Paper›PMID 41125392›Full record

ArticleMagnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine2026

Evaluation of Articular Cartilage in Knee Osteoarthritis Using Macromolecular Proton Fraction Mapping.

Mio Ariki, Yasuhiro Fujiwara, Motohira Mio, Kosuke Yamashita, Mika Kitajima

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Article in Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Mio ArikiGraduate School of Health Sciences, Kumamoto University, Kumamoto, Kumamoto, Japan.
Yasuhiro FujiwaraDepartment of Medical Imaging Technology, Faculty of Life Sciences, Kumamoto University, Kumamoto, Kumamoto, Japan.
Motohira MioDepartment of Radiology, Fukuoka University Chikushi Hospital, Chikushino, Fukuoka, Japan.
Kosuke YamashitaDepartment of Medical Imaging Technology, Faculty of Life Sciences, Kumamoto University, Kumamoto, Kumamoto, Japan.
Mika KitajimaDepartment of Diagnostic Imaging Technology, Faculty of Life Sciences, Kumamoto University, Kumamoto, Kumamoto, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo evaluate the clinical utility of macromolecular proton fraction mapping for early osteoarthritis detection and compare its effectiveness with T

methodsEleven controls and 29 patients with osteoarthritis underwent 3.0T magnetic resonance imaging. Patients were classified based on the Kellgren-Lawrence grading system into mild osteoarthritis (KL 1-2, n = 9) and severe (KL 3-4, n = 20) osteoarthritis. Macromolecular proton fraction maps were generated from proton density-, T

resultsMacromolecular proton fraction values decreased with increasing osteoarthritis severity. Compared to controls, both the mild and severe osteoarthritis groups exhibited significantly lower macromolecular proton fraction in the medial anterior and medial posterior regions. Additionally, the severe osteoarthritis group demonstrated significantly lower macromolecular proton fraction values in the medial central and lateral posterior regions compared to controls. In contrast, T

conclusionMacromolecular proton fraction mapping demonstrated sensitivity to early-stage cartilage degeneration in osteoarthritis, suggesting its potential as a biomarker for early osteoarthritis detection. The combination of macromolecular proton fraction and T

Indexed as

Cartilage, ArticularMagnetic Resonance ImagingOsteoarthritis, KneeAdultAgedAlgorithmsFemaleHumansKnee JointMaleMiddle AgedProtonsSeverity of Illness IndexProtonsarticular cartilagekneemacromolecularosteoarthritisquantitative magnetic resonance imaging

Identifiers

PMID41125392
PMCPMC13217289

What Socratic holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.