ArticleScientific reports2025
The surface and micellar properties of ethanolamine based surface active ionic liquids in the presence of drug aspirin.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Effects of some surface active ionic liquids on the aqueous solubility, thermodynamic properties and fluorescence behavior of drug diclofenac sodium.Scientific reports · 2026Article
- Development and Characterization of Quinoa Peptide Nanoparticles as Carriers for Bioactive Food Ingredient Encapsulation.Foods (Basel, Switzerland) · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bio-based surface-active ionic liquids (SAILs) offer promising advantages for pharmaceutical applications, particularly in enhancing drug solubility and bioavailability. Aspirin, classified under the Biopharmaceutics Classification System (BCS) as poorly soluble in the gastrointestinal tract, require effective solubilization strategies for improved therapeutic efficacy. This study investigates the micellization behavior and thermophysical properties of three natural based SAILs (2-hydroxyethyl)ammonium oleate ([2-HEA][Ole]), bis(2-hydroxyethyl)ammonium oleate ([BHEA][Ole]), and tris(2-hydroxyethyl)ammonium oleate ([THEA][Ole]) in aqueous solutions of aspirin at 298 K. Micellization characteristics, including critical micelle concentration (CMC), were determined using electrical conductivity and surface tension measurements for SAILs in the presence of the aspirin aqueous solutions systems at 298 K. Key interfacial parameters such as interface surface pressure (Π), minimum surface area occupied per molecule ([Formula: see text]), Gibbs maximum excess surface concentration ([Formula: see text]) were also calculated. Additionally, the Conductor-like Screening Model (COSMO) was employed to elucidate molecular interactions between SAILs and the studied drug. The results indicate that CMC values decrease in the presence of aspirin. Among the studied systems, [THEA][Ole] exhibited the lowest CMC, as determined by electrical conductivity and surface tension measurements, particularly in the presence of higher concentrations of aspirin in aqueous media. Furthermore, COSMO analysis revealed that [THEA][Ole], possessing the highest surface cavity volume (V), demonstrated the most favorable interactions with aspirin, highlighting its potential as an effective solubilizing agent. Finally, interactions between SAILs and aspirin were investigated through limiting molar conductivity [Formula: see text] , and association constant [Formula: see text] , determination.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.