Evidence map›Paper›PMID 41125818›Full record

ArticleScientific reports2025

Unravelling pain in Göttingen Minipigs undergoing experimentally induced closed-chest myocardial infarction: a prospective cohort study.

Mariafrancesca Petrucci, Anne-Christine Uldry, Chiara Parodi, Luisana Gisela Garcia Casalta, Alain Despont, Noé Corpataux, Fabien Praz, Robert Rieben, Daniela Casoni

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In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Mariafrancesca PetrucciExperimental Surgery Facility (ESF), Experimental Animal Center (EAC), Faculty of Medicine, University of Bern, Bern, Switzerland. mariafrancesca.petrucci@umontreal.ca.
Anne-Christine UldryProteomics and Mass Spectrometry Core Facility, Department for BioMedical Research, University of Bern, Bern, Switzerland.
Chiara ParodiExperimental Surgery Facility (ESF), Experimental Animal Center (EAC), Faculty of Medicine, University of Bern, Bern, Switzerland.
Luisana Gisela Garcia CasaltaExperimental Surgery Facility (ESF), Experimental Animal Center (EAC), Faculty of Medicine, University of Bern, Bern, Switzerland.
Alain DespontDepartment for BioMedical Research, Faculty of Medicine, University of Bern, Bern, Switzerland.
Noé CorpatauxDepartment of Cardiology, Inselspital, University of Bern, Bern, Switzerland.
Fabien PrazDepartment of Cardiology, Inselspital, University of Bern, Bern, Switzerland.
Robert RiebenDepartment for BioMedical Research, Faculty of Medicine, University of Bern, Bern, Switzerland.
Daniela CasoniExperimental Surgery Facility (ESF), Experimental Animal Center (EAC), Faculty of Medicine, University of Bern, Bern, Switzerland. daniela.casoni@unibe.ch.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The pain associated with experimental myocardial infarction in pigs has never been investigated. We aimed at assessing pain and its correlation with myocardial damage. Twenty-four Göttingen minipigs undergoing closed chest myocardial infarction followed by coronary reperfusion under general balanced anaesthesia were included in the trial. Pain was assessed through mechanical and thermal thresholds, sensitivity to Von Frey filaments and behavioural indicators before (Pre MI), the day after (Post MI) and at the study endpoint (Post MI-endpoint). Over time differences in mechanical thresholds (MT) and thermal thresholds (TT) were assessed using one-sample t-test and their correlations with troponin I/cytokines using logistic regression. In four minipigs at Post MI acute pain requiring analgesia was identified. Pain thresholds decreased significantly at Post MI (MT: 51 [35.6; 74] TT: 44.8 [42.7; 48.7]) and Post MI-endpoint (MT: 47.5 [35; 64.3]; TT: 44.3 [43.1; 48.6]) compared to Pre MI (MT: 72 [53.4; 84], TT: 46.3 [43.8; 53.8]). The response to von Frey filaments remained sporadic. Troponin I highly increased at Post MI, but no correlations with pain thresholds were found. Following balanced anaesthesia, acute pain had low incidence and mild to moderate intensity. Somatic hyperalgesia remained until the study endpoint, but its relevance remains to be unravelled.

Indexed as

Myocardial InfarctionPainAnimalsDisease Models, AnimalFemaleMalePain MeasurementPain ThresholdProspective StudiesSwineSwine, MiniatureTroponin ITroponin IBehavioursBiomedical researchCardiovascular diseasePainQuantitative sensory testingSwine

Identifiers

PMID41125818
PMCPMC12546812

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.