Evidence map›Paper›PMID 41125900›Full record

ReviewNeurosurgical review2025

A refined treatment strategy for skull base chordoma: A protocol and management algorithm.

Zachary C Gersey, Hussam Abou-Al-Shaar, David T Fernandes Cabral, Ali A Alattar, Hussein M Abdallah, Michael M McDowell, Eric W Wang, Carl H Snyderman, Garret Choby, Paul A Gardner and 1 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Neurosurgical review, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Zachary C GerseyDepartment of Neurological Surgery, University of Pittsburgh, Pittsburgh, PA, USA.
Hussam Abou-Al-ShaarDepartment of Neurological Surgery, University of Pittsburgh, Pittsburgh, PA, USA.
David T Fernandes CabralDepartment of Neurological Surgery, University of Pittsburgh, Pittsburgh, PA, USA.
Ali A AlattarDepartment of Neurological Surgery, University of Pittsburgh, Pittsburgh, PA, USA.
Hussein M AbdallahDepartment of Neurological Surgery, University of Pittsburgh, Pittsburgh, PA, USA.
Michael M McDowellDepartment of Neurological Surgery, University of Pittsburgh, Pittsburgh, PA, USA.
Eric W WangDepartment of Otolaryngology, University of Pittsburgh, Pittsburgh, PA, USA.
Carl H SnydermanDepartment of Otolaryngology, University of Pittsburgh, Pittsburgh, PA, USA.
Garret ChobyDepartment of Otolaryngology, University of Pittsburgh, Pittsburgh, PA, USA.
Paul A GardnerDepartment of Neurological Surgery, University of Pittsburgh, Pittsburgh, PA, USA.
Georgios A ZenonosDepartment of Neurological Surgery, Center for Cranial Base Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA, USA. zenonosg2@upmc.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Skull base chordomas (SBCs) are rare and challenging tumors due to their midline location and invasive behavior, requiring a multidisciplinary approach that integrates advancements in surgical techniques, radiation therapy, and emerging therapies. This paper synthesizes clinical experience with 307 surgical resections performed on 197 patients to propose a cohesive treatment paradigm for SBCs. The endoscopic endonasal approach (EEA) is highlighted as a cornerstone of surgical management, with key considerations for postoperative radiation strategies and novel therapeutic options, such as immunotherapy, discussed. By emphasizing the importance of maximal safe resection, individualized treatment planning, and ongoing innovation, this paper aims to provide a framework for optimizing outcomes in patients with SBCs while highlighting areas for future research in this complex field.

Indexed as

AlgorithmsChordomaNeurosurgical ProceduresSkull Base NeoplasmsAdultFemaleHumansMaleMiddle AgedNeuroendoscopyTreatment OutcomeChordomaClival chordomaGeneticsManagement algorithmRadiotherapySkull base

Identifiers

PMID41125900
PMCPMC12546311

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.