ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2026
DKK2 contributes to context discrimination and adult hippocampal neurogenesis by suppressing Wnt/PCP signaling.
Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed.
- Multi-omics analysis reveals the effects of Codonopsis pilosula polysaccharides on the skeletal muscle development of Sansui ducks during the embryonic stage.Poultry science · 2026Article
- Stem cell activation in organ culture reveals novel transcriptional programs underlying metabolic, fibrotic, vascular, and immune dysregulation in uterine leiomyomas.Frontiers in cell and developmental biology · 2026Article
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Authors and funding
7 authors.
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Abstract
Wnt signaling plays a pivotal role in normal brain development and function. Dickkopf-related protein 2 (DKK2), a member of the DKK protein family (DKK1 - 4), modulates Wnt signaling either positively or negatively by interacting with the WNT co-receptors low-density lipoprotein receptor-related proteins 5 and 6 (Lrp5/6). However, the role of DKK2 in the brain remains unclear. Here, we demonstrated that the DKK2-mediated suppression of Wnt signaling is essential for hippocampal function. Dkk2
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Registered trials
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