Evidence map›Paper›PMID 41126316›Full record

Observational studyEuropean journal of medical research2025

Sarcopenic obesity exacerbates gastric cancer prognosis via increased intermuscular and visceral fat accumulation.

Chun-Wei Li, Qi Li, Yu Liu, Yu Zhang, Zhong-Kui Wang, Yu Xing, Yi-Shan Niu, Yi Pang, Kang Yu

Registry-linked trialAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in European journal of medical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02873676 (Prevalence and the Effect of Lifestyle Modification Project), which is not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02873676 naunknown statusnot on this map

Prevalence and the Effect of Lifestyle Modification Project (LMP) on Clinical Outcomes and Cost-effectiveness Ratio for Sarcopenia in Chinese Adults and Elderly: a Multicenter Randomized Controlled Trail

TypeinterventionalSponsorPeking Union Medical College HospitalRan2016 to 2020Enrolled200ConditionsSarcopeniaArmsnutritional intervention, resistance training program, lifestyle modification project, control
3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Chun-Wei Li *Department of Clinical Nutrition, Institute of Clinical Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, No. 1 ShuaiFu Yuan, Dongcheng District, Beijing, 100730, China.ORCID http://orcid.org/0009-0008-5777-5989
Qi Li *Department of General Surgery, Central Hospital, Tianjin University (The Third Central Hospital of Tianjin), No.83 Jintang Road, Hedong District, Tianjin, 300170, China.ORCID http://orcid.org/0000-0002-6149-8127
Yu Liu *Department of General Surgery, Central Hospital, Tianjin University (The Third Central Hospital of Tianjin), No.83 Jintang Road, Hedong District, Tianjin, 300170, China.ORCID http://orcid.org/0009-0005-0860-1876
Yu ZhangDepartment of Clinical Nutrition, Department of Health Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, No. 1 ShuaiFu Yuan, Dongcheng District, Beijing, 100730, China.ORCID http://orcid.org/0009-0008-9259-9781
Zhong-Kui WangDepartment of General Surgery, Central Hospital, Tianjin University (The Third Central Hospital of Tianjin), No.83 Jintang Road, Hedong District, Tianjin, 300170, China.ORCID http://orcid.org/0000-0002-1763-4486
Yu XingDepartment of General Surgery, Central Hospital, Tianjin University (The Third Central Hospital of Tianjin), No.83 Jintang Road, Hedong District, Tianjin, 300170, China.ORCID http://orcid.org/0000-0001-8075-9612
Yi-Shan NiuDepartment of General Surgery, Central Hospital, Tianjin University (The Third Central Hospital of Tianjin), No.83 Jintang Road, Hedong District, Tianjin, 300170, China.ORCID http://orcid.org/0009-0000-1253-442X
Yi PangDepartment of General Surgery, Central Hospital, Tianjin University (The Third Central Hospital of Tianjin), No.83 Jintang Road, Hedong District, Tianjin, 300170, China. tjnkpy2015@sina.com.ORCID http://orcid.org/0009-0009-5517-3770
Kang YuDepartment of Clinical Nutrition, Department of Health Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, No. 1 ShuaiFu Yuan, Dongcheng District, Beijing, 100730, China. yuk1997@sina.com.ORCID http://orcid.org/0000-0002-6939-7275

Funding

China Postdoctoral Science Foundation 2023M730321National High Level Hospital Clinical Research Funding 2022-PUMCH-B-055National Key R&D Program of China 2022YFF1100600/2022YFF1100604National Natural Science Foundation of China 82404264Postdoctoral Fellowship Program of CPSF GZC20230296Whole People Nutrition Research Fund CNSNNSRG2021-129
6 · The paper itself

Abstract

backgroundEctopic fat distribution reflects patient's metabolic profile, shaping the tumor microenvironment, which may be a key prognostic indicator. Our study pursues to explore the independent and combined effects of muscle atrophy and abnormal fat distribution on survival in gastric cancer patients.

methodThis retrospective cohort study analyzed body composition in 283 gastric cancer patients from Center Hospital, Tianjin University (June 2016-May 2025) using pretreatment CT at L

resultsOf the 283 patients, 32 patients (11.3%) were BMI-define obese, 139 patients (49.1%) showed visceral obesity, and 176 patients (62.2%) presented with myosteatosis. Sarcopenia was present in 234 patients (82.7%), and 151 patients (53.4%) presented with a combination of sarcopenia and myosteatosis. During a median follow-up of 41 months (2-108 months), 53 patients developed metastasis, 6 relapse, and 142 died. Skeletal muscle mass (Normal Attenuation Muscle Area, NAMA, HR = 0.989, 95% CI 0.980-0.998, P = 0.022, for PFS) and quality (SMD, HR = 0.975, 95% CI 0.955-0.995, P = 0.013, for PFS) serve as protective prognostic factors after multiple covariate adjustments. Multivariate analyses identified all adiposity-related parameters, including Low Attenuation Muscle Area (LAMA, HR = 1.015, 95% CI 1.003-1.026, P = 0.012, for PFS), intermuscular adipose tissue (IMAT, HR = 1.018, 95% CI 1.002-1.034, P = 0.027, for PFS), and VFI (HR = 1.008, 95% CI 1.001-1.015, P = 0.042) as negative indicators for survival. Sensitivity analyses confirmed these associations. Besides, IMAT, LAMA, and VFI significantly influence prognosis in advanced patients (TNM stage III-IV). Kaplan-Meier survival analysis revealed sarcopenic visceral obesity markedly reduces survival; when combined with myosteatosis (SMVO), this combined phenotype further exacerbated CRS (5-year CRS: 74.7% in SMVO, P = 0.019) beyond the effects of individual phenotypes.

conclusionSarcopenic obesity (myosteatosis/visceral obesity) can identify poorer prognosis in gastric cancer patients, especially male patients. It is crucial for obese gastric cancer patients to evaluate their body composition, specifically focusing on fat distribution.

trial registrationRegistered in August 2016, NCT02873676 at www. CLINICALTRIALS: gov .

Indexed as

Intra-Abdominal FatObesitySarcopeniaStomach NeoplasmsAdultAgedBody CompositionFemaleHumansMaleMiddle AgedMuscle, SkeletalObesity, AbdominalPrognosisRetrospective StudiesEctopic fat accumulationGastric cancerIntermuscular adipose tissueSarcopenic obesitySurvival

Identifiers

PMID41126316
PMCPMC12542074

What Socratic holds

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LicenceCC BY-NC-ND
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.