Evidence map›Paper›PMID 41126352›Full record

ArticleActa neuropathologica communications2025

Inflammation of central nervous system fiber tracts is active in patients over six months post-intracerebral hemorrhage.

Zhuyu Gao, Kunbin Lian, Fuxin Lin, Wei Chen, Huangcheng Shangguan, Lingyun Zhuo, Yan Zheng, Xintong Yu, Jie Lin, Guanyu Dong and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta neuropathologica communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Zhuyu Gao *Department of Neurosurgery, Department of Neurology, First Affiliated Hospital, Fujian Medical University, No.20 Chazhong Rd, Fuzhou, 350005, Fujian, China.
Kunbin Lian *Department of Neurosurgery, Department of Neurology, First Affiliated Hospital, Fujian Medical University, No.20 Chazhong Rd, Fuzhou, 350005, Fujian, China.
Fuxin Lin *Department of Neurosurgery, Department of Neurology, First Affiliated Hospital, Fujian Medical University, No.20 Chazhong Rd, Fuzhou, 350005, Fujian, China.
Wei Chen *Department of Neurosurgery, Department of Neurology, First Affiliated Hospital, Fujian Medical University, No.20 Chazhong Rd, Fuzhou, 350005, Fujian, China.
Huangcheng ShangguanDepartment of Neurosurgery, Department of Neurology, First Affiliated Hospital, Fujian Medical University, No.20 Chazhong Rd, Fuzhou, 350005, Fujian, China.
Lingyun ZhuoDepartment of Neurosurgery, Department of Neurology, First Affiliated Hospital, Fujian Medical University, No.20 Chazhong Rd, Fuzhou, 350005, Fujian, China.
Yan ZhengDepartment of Neurosurgery, Department of Neurology, First Affiliated Hospital, Fujian Medical University, No.20 Chazhong Rd, Fuzhou, 350005, Fujian, China.
Xintong YuDepartment of Neurosurgery, Department of Neurology, First Affiliated Hospital, Fujian Medical University, No.20 Chazhong Rd, Fuzhou, 350005, Fujian, China.
Jie LinDepartment of Neurosurgery, Department of Neurology, First Affiliated Hospital, Fujian Medical University, No.20 Chazhong Rd, Fuzhou, 350005, Fujian, China.
Guanyu DongDepartment of Neurosurgery, Department of Neurology, First Affiliated Hospital, Fujian Medical University, No.20 Chazhong Rd, Fuzhou, 350005, Fujian, China.
Youliang WangDepartment of Neurosurgery, Department of Neurology, First Affiliated Hospital, Fujian Medical University, No.20 Chazhong Rd, Fuzhou, 350005, Fujian, China.
Wenhua FangDepartment of Neurosurgery, Department of Neurology, First Affiliated Hospital, Fujian Medical University, No.20 Chazhong Rd, Fuzhou, 350005, Fujian, China.
Yuanxiang LinDepartment of Neurosurgery, Department of Neurology, First Affiliated Hospital, Fujian Medical University, No.20 Chazhong Rd, Fuzhou, 350005, Fujian, China.
Dezhi KangDepartment of Neurosurgery, Department of Neurology, First Affiliated Hospital, Fujian Medical University, No.20 Chazhong Rd, Fuzhou, 350005, Fujian, China. kdz99988@vip.sina.com.
Ying FuDepartment of Neurosurgery, Department of Neurology, First Affiliated Hospital, Fujian Medical University, No.20 Chazhong Rd, Fuzhou, 350005, Fujian, China. fuying@fjmu.edu.cn.

Funding

the Major Scientific Research Program for Young and Middle-aged Health Professionals of Fujian Province 2022ZQNZD005the Major Scientific Research Specialty Project of Fujian Province 2022ZD01003the National Natural Science Foundation of China 82371466the National Natural Science Foundation of China U21A20360the National Natural Science Foundation of China U24A20685
6 · The paper itself

Abstract

The occurrence and extent of central nervous system (CNS) fiber tract inflammation in chronic-phase intracerebral hemorrhage (ICH) patients are not well understood due to the heterogeneity of Wallerian degeneration (WD). This study aims to investigate the presence of CNS fiber tract inflammation in chronic-phase ICH patients and to characterize any inflammatory cells in the fiber tract. An in vivo translocator protein (TSPO)-PET study was undertaken in 22 ICH patients over 6 months after stroke who were admitted to the First Affiliated Hospital of Fujian Medical University or Tianjin Medical University General Hospital from April 2017 to June 2020. Twenty-three healthy controls or participants with various CNS diseases were included. Cerebral peduncle (CP) TSPO uptake was calculated as the average standardized uptake value ratio (SUVr). To aid interpretation of the TSPO uptake results at the CNS fiber tract level, spatial transcriptome sequencing was used to identify fiber tract inflammation in an ICH mouse model at 4wks post-onset and to characterize the cells present in the inflamed fiber tract. PET imaging showed that CP TSPO SUVr values in patients over 6 months since ICH were higher than in healthy controls (mean CP SUVr ± SD; ICH: 1.19 ± 0.11; control: 1.02 ± 0.08; P < 0.0001), and there was an obvious negative correlation between CP TSPO uptake and CP volume, which means that the CNS fiber tract inflammation persists and is still active in chronic-phase ICH patients, which may worsen their prognosis. Spatial transcriptome sequencing of the CNS fiber tract in ICH model mice identified a population of peripheral-derived pro-inflammatory macrophages contributing to the increased TSPO uptake. CP uptake was associated with frontal bone marrow uptake according to association analyses, indicating the cells possibly extending from the skull bone marrow into CNS in the chronic phase.

Indexed as

Cerebral HemorrhageInflammationNeuroinflammatory DiseasesAgedAnimalsFemaleHumansMaleMiceMiddle AgedPositron-Emission TomographyReceptors, GABAReceptors, GABATSPO protein, human18F-DPA714Chronic phaseHemorrhagic strokePositron emission tomographic imagingTranslocator protein

Identifiers

PMID41126352
PMCPMC12542097

What Socratic holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.