Trial reportJournal of rehabilitation medicine2025
From gains to decline: effects of structured pre-dialytic exercise training and detraining on physical fitness, quality of life, and inflammation in haemodialysis patients.
Trial report in Journal of rehabilitation medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05649657 (Effect of Lifestyle Intervention in Patients With Chronic Kidney Disease on Fitness and Immune Function), which is not on this map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effect of Lifestyle Intervention in Patients With Chronic Kidney Disease on Fitness and Immune Function
Who cites it
1 citing paper in PubMed.
- Differences in circulatory dynamics and skeletal muscle blood flow during exercise between post-dialysis and non-dialysis days in hemodialysis patients.International urology and nephrology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivePre-dialysis exercise training may benefit haemodialysis patients, but the effects of structured aerobic and resistance training remain unclear. This study evaluated the effects of a 6-month training performed 1-2 h before haemodialysis on muscle strength, cardiorespiratory fitness, quality of life, and systemic inflammation.
designA 3-phase self-controlled design: 3-month control, 6-month aerobic and resistance training (72 sessions) and nutrition counselling, and 3-month follow-up. PATIENTS: Haemodialysis patients > 3 months.
methodsAssessments were performed every 3 months at 5 time points. Outcomes included physical fitness (dual-energy X-ray absorptiometry, isokinetic dynamometry, and cardiopulmonary exercise testing), Kidney Disease QOL questionnaire, International Physical Activity Questionnaire, nutrition, and plasma pro- and anti-inflammatory cytokines.
resultsOf 118 patients screened, 29 entered training and 22 completed 72 sessions (92% compliance). Pre-dialysis exercise training improved muscle mass, cardiorespiratory fitness, quadriceps strength, physical and mental components, and disease-specific quality of life; cardiorespiratory fitness and strength declined at 3-month follow-up, but muscle mass remained. Cytokine levels were unchanged, suggesting minimal pro- or anti-inflammatory effects.
conclusionA 6-month pre-dialysis exercise programme improved cardiorespiratory fitness, strength, muscle mass, and quality of life with high compliance. It may be viable for haemodialysis patients, though maintenance is needed to sustain benefits. CLINICALTRIALS: gov ID: NCT05649657.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.