Evidence map›Paper›PMID 41126921›Full record

ArticleFrontiers in cardiovascular medicine2025

Comparison and identification of serum metabolomic profiles in Stage B and Stage C ejection fraction preserved heart failure.

Song Zou, Li-Wei Zhang, Ting Wang, Yu-Hao Wan, Ke Chai, Si-Ming Wang, Chen Meng, Jian-Ping Cai, Hua Wang, Jie-Fu Yang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cardiovascular medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Song ZouDepartment of Cardiology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Science & Peking Union Medical College, Beijing, China.
Li-Wei ZhangDepartment of Cardiology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Science & Peking Union Medical College, Beijing, China.
Ting WangDepartment of Cardiology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Science & Peking Union Medical College, Beijing, China.
Yu-Hao WanDepartment of Cardiology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Science & Peking Union Medical College, Beijing, China.
Ke ChaiDepartment of Cardiology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China.
Si-Ming WangThe Key Laboratory of Geriatrics, Beijing Institute of Geriatrics, Beijing Hospital, National Center of Gerontology, National Health Commission, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China.
Chen MengDepartment of Cardiology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China.
Jian-Ping CaiThe Key Laboratory of Geriatrics, Beijing Institute of Geriatrics, Beijing Hospital, National Center of Gerontology, National Health Commission, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China.
Hua WangDepartment of Cardiology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Science & Peking Union Medical College, Beijing, China.
Jie-Fu YangDepartment of Cardiology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Science & Peking Union Medical College, Beijing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Disturbed metabolism correlates with the progression of heart failure with preserved ejection fraction (HFpEF). However, the discrepancy in metabolism between asymptomatic (Stage B) and symptomatic (Stage C) HFpEF patients remains unclear. This study aimed to explore the metabolic differences between Stages B and C HFpEF patients and to screen metabolites to distinguish between the two groups of patients. Methods: A total of 97 Stage B and 31 Stage C HFpEF patients were included from a previous cohort, named Frailty and Comprehensive Geriatric Assessment in Hospitalized Elderly Patients (registration number: ChiCTR1800017204). Serum metabolites of the participants were identified and quantified using targeted metabolomics (Biocrates MxP® Quant 500 kit). Results: Differential analysis identified 208 metabolites of 19 categories, of which lipids ( Conclusion: Compared with Stage B control, Stage C patients suffer from extensive metabolic disorders, of which lipid metabolism and amino acid metabolism are mostly significantly impaired. The alterations of metabolites are largely attributed to renal dysfunction and muscle proteolysis. Moreover, non-heart-specific metabolites display potential diagnostic value in differentiating subgroups of patients with HFpEF.

Indexed as

bioinformaticsbiomarkerheart failure with preserved ejection fractionmetabolomicspathophysiology

Identifiers

PMID41126921
PMCPMC12537769

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.