Evidence map›Paper›PMID 41127091›Full record

ArticleFrontiers in nutrition2025

Predictive value of novel nutritional inflammation indexes in IVIG-unresponsive Kawasaki disease: a retrospective study.

Cong Yi, Dan Xue, Jia Chen, Jun Guo, Yu-Neng Zhou, Yu Hu, Xiang She

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Cong Yi *Department of Pediatrics, Mianyang Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Mianyang, China.
Dan Xue *Department of Pediatrics, Mianyang Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Mianyang, China.
Jia ChenDepartment of Pediatrics, Mianyang Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Mianyang, China.
Jun GuoDepartment of Pediatrics, Mianyang Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Mianyang, China.
Yu-Neng ZhouDepartment of Pediatrics, Mianyang Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Mianyang, China.
Yu HuDepartment of Pediatrics, Mianyang Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Mianyang, China.
Xiang SheDepartment of Pediatrics, Mianyang Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Mianyang, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: This retrospective study aimed to investigate the predictive value of novel albumin-associated nutritional inflammation markers, including the C-reactive protein-albumin-lymphocyte (CALLY) index, C-reactive protein to albumin ratio (CAR), neutrophil-to-albumin ratio (NAR), neutrophil percentage-to-albumin ratio (NPAR) and prognostic nutritional index (PNI), for intravenous immunoglobulin (IVIG) resistance in Kawasaki disease (KD) patients. Methods: We conducted a retrospective analysis of clinical data from pediatric patients diagnosed with KD and admitted to our hospital between January 2012 and November 2023. Data were analyzed using univariate analysis, binary logistic regression analysis, and receiver operating curve (ROC) analysis. Results: The study included 716 children with KD, and 78 of them (10.9%) were diagnosed with IVIG-resistant KD. CAR, NAR and NPAR were positively correlated with IVIG resistance, while the CALLY index and PNI showed negative correlations. The area under the ROC curve (AUC) values of the CALLY index, CAR, NAR, NPAR and PNI were 0.725, 0.700, 0.580, 0.717 and 0.712. Conclusion: Our findings suggest that these novel nutritional inflammation indexes could be useful tools for predicting IVIG resistance in KD patients, potentially guiding timely intensified therapy. Compared to NAR, the CALLY index, CAR, NPAR, and PNI demonstrate stronger predictive performance for intravenous immunoglobulin (IVIG) resistance in Kawasaki disease and may hold greater potential for clinical application.

Indexed as

C-reactive protein-albumin-lymphocyte indexC-reactive protein to albumin ratiointravenous immunoglobulin resistanceKawasaki diseaseneutrophil percentage-to-albumin rationeutrophil-to-albumin ratioprognostic nutritional index

Identifiers

PMID41127091
PMCPMC12537436

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.