ArticleNature and science of sleep2025
Association of Novel Hematologic Inflammatory Biomarkers with Cardiovascular Disease in Patients with Obstructive Sleep Apnea.
Article in Nature and science of sleep, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Sex-Specific Association Between the Neutrophil-to-HDL Cholesterol Ratio and Hyperuricemia in Obstructive Sleep Apnea.Journal of clinical medicine · 2026Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Heightened inflammatory state is considered a key factor linking obstructive sleep apnea (OSA) with cardiovascular disease (CVD). Objective: This study aimed to assess the level of novel hematologic inflammatory biomarkers including neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), ratio of neutrophil count to HDL level (NHR), ratio of monocyte count to HDL level (MHR), monocyte count multiplied by neutrophil-to-lymphocyte ratio (SIRI) in OSA patients, and explored the relationships between these inflammatory biomarkers and cardiovascular risk. Methods: This study enrolled 974 patients with OSA and all data were collected after admission. Spearman correlation was used to explore the correlations between sleep parameters and inflammatory indices. Logistic regression and receiver operating characteristic (ROC) analysis were employed to assess the association between the novel hematologic inflammatory indices and CVD in OSA patients. Results: Correlation analysis showed that most inflammatory indices were closely related to nocturnal hypoxia in OSA patients. Multivariate logistic regression suggested that NLR (OR=1.085, 95% CI: 1.017-1.158), MLR (OR=3.708, 95% CI: 1.322-10.404), NHR (OR=1.074, 95% CI: 1.020-1.131), MHR (OR=2.116, 95% CI: 1.205-3.715), and SIRI (OR=1.148, 95% CI: 1.035-1.272) were positively correlated with CVD in OSA patients after adjusting all confounding factors. Moreover, the area under the curve (AUC) of NLR, MLR, NHR, MHR, and SIRI for discriminating OSA patients with CVD was 0.734, 0.735, 0.736, 0.734, and 0.735, respectively, after adjusting for all confounders. Conclusion: Inflammatory indices including NLR, MLR, NHR, MHR, and SIRI were promising biomarkers for CVD in OSA patients, which might aid in the early identification of CVD risk in clinical. These easily obtainable markers may facilitate CVD risk stratification in OSA patients.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.