Evidence map›Paper›PMID 41127360›Full record

ArticleDrug design, development and therapy2025

Pharmacokinetics and Safety of Fospropofol Disodium for Injection in Subjects with Hepatic Impairment Compared with Healthy Matched Controls: A Prospective Cohort Study.

Rong Wang, Xiaojuan Jiang, Qiongfang Cao, Weiyi Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Drug design, development and therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Rong Wang *Department of Anesthesiology, West China Hospital, Sichuan University, Chengdu, Sichuan, People's Republic of China.
Xiaojuan Jiang *Department of Anesthesiology, West China Hospital, Sichuan University, Chengdu, Sichuan, People's Republic of China.
Qiongfang CaoDepartment of Anesthesiology, West China Hospital, Sichuan University, Chengdu, Sichuan, People's Republic of China.
Weiyi ZhangDepartment of Anesthesiology, West China Hospital, Sichuan University, Chengdu, Sichuan, People's Republic of China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: Fospropofol disodium for injection (Fospropofol Patients and Methods: Twenty-three patients were enrolled and divided into three cohorts according to liver function: normal liver function (n = 10), moderate hepatic impairment (n = 10), and severe hepatic impairment (n = 3). They received a single bolus of Fospropofol Results: Compared with matched healthy controls, patients with moderate hepatic impairment exhibited significant reduced exposure and increased elimination for Fospropofol Conclusion: Our study is the first to report altered PK of Fospropofol

Indexed as

Anesthetics, IntravenousLiver DiseasesPropofolAdultAgedCase-Control StudiesCohort StudiesFemaleHumansMaleMiddle AgedProspective StudiesTandem Mass SpectrometryAnesthetics, IntravenousfospropofolPropofolfospropofol disodiumhepatic impairmentpharmacokineticpropofolsafety

Identifiers

PMID41127360
PMCPMC12539353

What Socratic holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.