ReviewCureus2025
The Effects of Multimodal Prehabilitation on Postoperative Outcomes in Colorectal Surgery: A Systematic Review and Meta-Analysis.
Review in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed.
- Multimodal prehabilitation versus no prehabilitation to improve functional capacity, reduce postoperative complications and improve quality of life in colorectal cancer surgery.The Cochrane database of systematic reviews · 2026Article
- Non-Pharmacological Prehabilitation in Surgical Patients with Pre-Existing Chronic Cardio-Respiratory Disease: A Clinically Oriented Narrative Review.Healthcare (Basel, Switzerland) · 2026Review
- Prehabilitation in Colorectal Cancer Surgery: A Narrative Review of Current Evidence and Clinical Perspectives.Nutrients · 2026Review
- Practices in prehabilitation and follow-up after hernia surgery: a global survey of 135 surgeons from 20 countries.Surgical endoscopy · 2026Article
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Colorectal surgery carries risks of functional decline and complications. Multimodal prehabilitation, integrating exercise, nutrition, and psychological support, may enhance recovery alongside Enhanced Recovery After Surgery (ERAS) pathways. This review evaluated its impact on postoperative outcomes. A systematic review and meta-analysis were conducted using a standardized and transparent methodology to ensure comprehensive and unbiased reporting. PubMed, Embase (via Ovid), MEDLINE (via Ovid), and Cochrane Central were searched for randomized controlled trials (RCTs). Eligible trials compared multimodal prehabilitation with standard care in elective colorectal resections. The primary outcome was overall postoperative complications; secondary outcomes included functional capacity by the six-minute walk test (6MWT) and severe complications (Clavien-Dindo ≥III). Five RCTs (422 patients) were included. Prehabilitation significantly lowered overall postoperative complications compared with standard of care (OR: 0.60, 95% CI: 0.42-0.86; p=0.02; I²=0%). Functional recovery was improved, with a pooled mean 6MWT difference at eight weeks of +50.8 m (95% CI: 25.9-75.7; p<0.0001; I²=59%). No significant reduction was observed for severe complications (OR: 0.65, 95% CI: 0.13-3.29; p=0.37; I²=20%). Multimodal prehabilitation improves functional recovery and reduces overall complications in colorectal cancer surgery, though its effect on severe complications remains uncertain. Larger multicenter trials are needed to strengthen the evidence base.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.