Evidence map›Paper›PMID 41127897›Full record

Trial reportMovement disorders : official journal of the Movement Disorder Society2026

Transcranial Ultrasound Stimulation of Internal Globus Pallidus Region and Motor Cortex in Parkinson's Disease.

Yi-Ying Lin, Nasem Raies, Talyta Grippe, Carolyn A Gunraj, Can Sarica, Utpal Kumar Saha, Amitabh Bhattacharya, Ghazaleh Darmani, Robert Chen

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Movement disorders : official journal of the Movement Disorder Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Transcranial Pulse Stimulation Enhances Dexterity in Parkinson's Disease: A Randomized Sham-Controlled Trial.Movement disorders : official journal of the Movement Disorder Society · 2026
    Trial
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yi-Ying LinKrembil Research Institute, University Health Network, Toronto, Ontario, Canada.ORCID https://orcid.org/0000-0002-2464-4498
Nasem RaiesKrembil Research Institute, University Health Network, Toronto, Ontario, Canada.
Talyta GrippeDivision of Neurology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada.
Carolyn A GunrajKrembil Research Institute, University Health Network, Toronto, Ontario, Canada.
Can SaricaKrembil Research Institute, University Health Network, Toronto, Ontario, Canada.ORCID https://orcid.org/0000-0001-8419-7426
Utpal Kumar SahaKrembil Research Institute, University Health Network, Toronto, Ontario, Canada.
Amitabh BhattacharyaKrembil Research Institute, University Health Network, Toronto, Ontario, Canada.
Ghazaleh DarmaniKrembil Research Institute, University Health Network, Toronto, Ontario, Canada.
Robert ChenKrembil Research Institute, University Health Network, Toronto, Ontario, Canada.

Funding

the Canadian Institutes of Health Research ENG 173742the Canadian Institutes of Health Research FDN 154292the Canadian Institutes of Health Research PJT 198046
6 · The paper itself

Abstract

backgroundMany patients with Parkinson's disease (PD) have motor impairments despite dopaminergic therapy. Low-intensity transcranial ultrasound stimulation (TUS) is a non-invasive neuromodulation method with high spatial precision. The effects of motor cortex (M1) and internal globus pallidus (GPi) TUS on PD motor signs and cortical excitability are still uncertain.

objectivesTo compare the effects of M1 theta burst TUS (tbTUS), GPi region tbTUS, and dual-site (M1 + GPi region) tbTUS on neurophysiology and motor signs in PD patients.

methodsSequential bilateral real M1/sham GPi, real GPi/sham M1, and simultaneous dual-site tbTUS were administered in three separate study visits in random order to 13 PD patients. Movement Disorder Society-sponsored revision of the Unified Parkinson's Disease Rating Scale-Part III (MDS-UPDRS-III) scores and transcranial magnetic stimulation measures of cortical excitability were recorded at baseline and at several time points up to 60 min after sonication.

resultsMDS-UPDRS-III scores and bradykinesia subscores decreased compared with baseline after GPi tbTUS at 30 min after sonication. Motor evoked potential (MEP) ratio to baseline increased after M1 tbTUS compared with GPi tbTUS at 10 min after sonication (T10). The stimulation intensity to elicit 1 mV MEP ratio to baseline in the GPi tbTUS condition was higher compared with baseline and with M1 tbTUS and dual-site tbTUS at T10. MEP amplitudes and MDS-UPDRS-III scores did not significantly change after the M1 and dual-site tbTUS conditions.

conclusionsBilateral GPi region tbTUS is a potential non-invasive approach for improving motor signs in PD patients, particularly bradykinesia. © 2025 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.

Indexed as

Globus PallidusMotor CortexParkinson DiseaseAgedEvoked Potentials, MotorFemaleHumansMaleMiddle AgedTranscranial Magnetic Stimulationinternal globus palliduslow‐intensity focused ultrasoundlow‐intensity transcranial ultrasound stimulationmotor cortexParkinson's diseaseTUS

Identifiers

PMID41127897
PMCPMC12951266

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.