Evidence map›Paper›PMID 41128499›Full record

ArticleAntimicrobial agents and chemotherapy2025

Genome-wide screen reveals glycerol-induced aminoglycoside potentiation against

Yaqin Xing, Mengmeng Bian, Xuebing Huang, Boyan Lv, Zhijie Huang, Xianzhang Jiang, Weiya Huang, Huping Xue, Hangyu Zhao, Jianfeng Huang and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yaqin Xing *Provincial University Key Laboratory of Cellular Stress Response and Metabolic Regulation, College of Life Sciences, Fujian Normal University, Fuzhou, Fujian, China.
Mengmeng Bian *Provincial University Key Laboratory of Cellular Stress Response and Metabolic Regulation, College of Life Sciences, Fujian Normal University, Fuzhou, Fujian, China.
Xuebing Huang *Provincial University Key Laboratory of Cellular Stress Response and Metabolic Regulation, College of Life Sciences, Fujian Normal University, Fuzhou, Fujian, China.
Boyan Lv *Provincial University Key Laboratory of Cellular Stress Response and Metabolic Regulation, College of Life Sciences, Fujian Normal University, Fuzhou, Fujian, China.
Zhijie HuangProvincial University Key Laboratory of Cellular Stress Response and Metabolic Regulation, College of Life Sciences, Fujian Normal University, Fuzhou, Fujian, China.
Xianzhang JiangProvincial University Key Laboratory of Cellular Stress Response and Metabolic Regulation, College of Life Sciences, Fujian Normal University, Fuzhou, Fujian, China.
Weiya HuangProvincial University Key Laboratory of Cellular Stress Response and Metabolic Regulation, College of Life Sciences, Fujian Normal University, Fuzhou, Fujian, China.
Huping XueDepartment of Animal Science and Technology, University of Northwest A&F, Yangling, Shaanxi, China.ORCID 0000-0002-7808-7164
Hangyu ZhaoProvincial University Key Laboratory of Cellular Stress Response and Metabolic Regulation, College of Life Sciences, Fujian Normal University, Fuzhou, Fujian, China.
Jianfeng HuangProvincial University Key Laboratory of Cellular Stress Response and Metabolic Regulation, College of Life Sciences, Fujian Normal University, Fuzhou, Fujian, China.
Xinmiao FuProvincial University Key Laboratory of Cellular Stress Response and Metabolic Regulation, College of Life Sciences, Fujian Normal University, Fuzhou, Fujian, China.ORCID 0000-0003-3361-6904

Funding

National Natural Science Foundation of China 82372295
6 · The paper itself

Abstract

Potentiation of existing antibiotics represents a promising strategy for combating the global health crisis of antibiotic resistance. Here we report that 1 min co-treatment with glycerol markedly enhances aminoglycoside efficacy against stationary-phase

Indexed as

AminoglycosidesAnti-Bacterial AgentsEnergy MetabolismGlycerolGlycerol KinaseStaphylococcus aureusAnimalsBacterial ProteinsBiofilmsDrug SynergismMethicillin-Resistant Staphylococcus aureusMiceMicrobial Sensitivity TestsStaphylococcal InfectionsAminoglycosidesAnti-Bacterial AgentsBacterial ProteinsGlycerolGlycerol Kinaseaminoglycosideantibiotic resistancebacterial persisterenergy metabolismglycerolMRSAPMF

Identifiers

PMID41128499
PMCPMC12691589

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.