Evidence map›Paper›PMID 41128926›Full record

Observational studyJournal of neurology2025

Intravenous thrombolysis in patients with acute ischaemic stroke and active cancer (the ITACA-stroke study).

Virginia Cancelloni, Giovanni Merlino, Gianluca Costamagna, Patrik Michel, Marialuisa Zedde, Ilaria Grisendi, Rosario Pascarella, Marina Padroni, Gianvito Barbella, Walter Ageno and 57 more

Abstract readObservational StudyMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Journal of neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

67 authors.

Virginia CancelloniStroke Unit and Division of Cardiovascular Medicine, University of Perugia, Perugia, Italy. virginia.cancelloni@gmail.com.ORCID http://orcid.org/0000-0003-0986-6575
Giovanni MerlinoSOSD Stroke Unit, Department of Head-Neck and Neuroscience, Azienda Sanitaria Universitaria Friuli Centrale (ASUFC), Udine, Italy.
Gianluca CostamagnaStroke Centre, Neurology Service, Department of Clinical Neurosciences, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
Patrik MichelStroke Centre, Neurology Service, Department of Clinical Neurosciences, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
Marialuisa ZeddeNeurology Unit, Stroke Unit, Azienda Unità Sanitaria Locale-IRCCS di Reggio Emilia, Reggio Emilia, Italy.
Ilaria GrisendiNeurology Unit, Stroke Unit, Azienda Unità Sanitaria Locale-IRCCS di Reggio Emilia, Reggio Emilia, Italy.
Rosario PascarellaNeuroradiology Unit, Azienda Unità Sanitaria Locale-IRCCS di Reggio Emilia, Reggio Emilia, Italy.
Marina PadroniStroke Unit, Azienda Ospedaliero-Universitaria di Ferrara, Ferrara, Italy.
Gianvito BarbellaStroke Unit, Azienda Ospedaliero-Universitaria di Ferrara, Ferrara, Italy.
Walter AgenoDepartment of Medicine and Surgery, University of Insubria, Varese, Italy.
Elisa RuggeriDepartment of Medicine and Surgery, University of Insubria, Varese, Italy.
Simona SaccoDepartment of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy.
Alessio TroisiDepartment of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy.
Raffaele OrnelloDepartment of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy.
Marina ManninoDepartment of Neurology and Stroke Unit, Azienda Ospedaliera Ospedali Riuniti Villa Sofia-V. Cervello, Palermo, Italy.
Valeria TerrusoDepartment of Neurology and Stroke Unit, Azienda Ospedaliera Ospedali Riuniti Villa Sofia-V. Cervello, Palermo, Italy.
Roberto SperottoSOSD Stroke Unit, Department of Head-Neck and Neuroscience, Azienda Sanitaria Universitaria Friuli Centrale (ASUFC), Udine, Italy.
Arianna CellaSOSD Stroke Unit, Department of Head-Neck and Neuroscience, Azienda Sanitaria Universitaria Friuli Centrale (ASUFC), Udine, Italy.
Mariarosaria ValenteSOSD Stroke Unit, Department of Head-Neck and Neuroscience, Azienda Sanitaria Universitaria Friuli Centrale (ASUFC), Udine, Italy.
Eugenia RotaNeurology Unit, S. Giacomo Hospital, ASL AL, Novi Ligure, Italy.
Manuel CappellariStroke Unit, Azienda Ospedaliera Universitaria Integrata, Verona, Italy.
Francesco VallettaStroke Unit, Azienda Ospedaliera Universitaria Integrata, Verona, Italy.
Mara ZenoriniStroke Unit, Azienda Ospedaliera Universitaria Integrata, Verona, Italy.
Matteo FoschiDepartment of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy.
Antonio GenoveseStroke Care Program, Emergency Department, Parma University Hospital, Parma, Italy.
Tiziana TassinariNeurology and Stroke Unit, Santa Corona Hospital, Pietra Ligure (SV), Italy.
Valentina SaiaNeurology and Stroke Unit, Santa Corona Hospital, Pietra Ligure (SV), Italy.
Valeria CasoStroke Unit and Division of Cardiovascular Medicine, University of Perugia, Perugia, Italy.
Cecilia BecattiniStroke Unit and Division of Cardiovascular Medicine, University of Perugia, Perugia, Italy.
Giorgio MarazitiStroke Unit and Division of Cardiovascular Medicine, University of Perugia, Perugia, Italy.
Ilaria Leone de MagistrisStroke Unit and Division of Cardiovascular Medicine, University of Perugia, Perugia, Italy.
Michele VentiStroke Unit and Division of Cardiovascular Medicine, University of Perugia, Perugia, Italy.
Andrea AlbertiStroke Unit and Division of Cardiovascular Medicine, University of Perugia, Perugia, Italy.
Alessandro PezziniDepartment of Medicine and Surgery, University of Parma, Parma, Italy.
Michelangelo MancusoNeurology Unit, Clinical and Experimental Medicine Department, Azienda Ospedaliero-Universitaria Pisana, Pisa, Italy.
Nicola GianniniNeurology Unit, Clinical and Experimental Medicine Department, Azienda Ospedaliero-Universitaria Pisana, Pisa, Italy.
Marco BaldiniNeurology Unit, Clinical and Experimental Medicine Department, Azienda Ospedaliero-Universitaria Pisana, Pisa, Italy.
Elisa GrifoniInternal Medicine II and Stroke Unit, S. Giuseppe Hospital, Empoli, Italy.
Luca MasottiInternal Medicine II and Stroke Unit, S. Giuseppe Hospital, Empoli, Italy.
Michele RomoliNeurology and Stroke Unit, Bufalini Hospital, AUSL Romagna, Cesena, Italy.
Sebastiano GiacomozziDepartment of Biomedical and Neuromotor Sciences (DIBINEM), Alma Mater Studiorum-University of Bologna, Bologna, Italy.
Georgios TsivgoulisSecond Department of Neurology, School of Medicine, National and Kapodistrian University of Athens, "Attikon" University Hospital, Athens, Greece.
Lina PalaiodimouSecond Department of Neurology, School of Medicine, National and Kapodistrian University of Athens, "Attikon" University Hospital, Athens, Greece.
Aikaterini TheodorouSecond Department of Neurology, School of Medicine, National and Kapodistrian University of Athens, "Attikon" University Hospital, Athens, Greece.
Odysseas KargiotisStroke Unit, Metropolitan Hospital, Piraeus, Greece.
George NtaiosDepartment of Internal Medicine, Faculty of Medicine, School of Health Sciences, University of Thessaly, Larissa, Greece.
Orestis TsiotsikasDepartment of Internal Medicine, Faculty of Medicine, School of Health Sciences, University of Thessaly, Larissa, Greece.
Efstathia KaragkioziDepartment of Internal Medicine, Faculty of Medicine, School of Health Sciences, University of Thessaly, Larissa, Greece.
Anastasia AdamouDepartment of Internal Medicine, Faculty of Medicine, School of Health Sciences, University of Thessaly, Larissa, Greece.
Paraskevi ValarakouDepartment of Internal Medicine, Faculty of Medicine, School of Health Sciences, University of Thessaly, Larissa, Greece.
Nemanja PopovicClinic of Neurology, University Clinical Centre of Vojvodina, Faculty of Medicine, University of Novi Sad, Novi Sad, Serbia.
Sanela PopovicClinic of Neurology, University Clinical Centre of Vojvodina, Faculty of Medicine, University of Novi Sad, Novi Sad, Serbia.
Pietro CaliandroStroke Unit, Neurology Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
Aurelia ZauliStroke Unit, Neurology Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
Giuseppe RealeUnit of High Intensity Neurorehabilitation, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
Marco MociUnit of High Intensity Neurorehabilitation, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
Laetitia YperzeeleStroke Unit and Neurovascular Centre, Department of Neurology, Antwerp University Hospital, Antwerp, Belgium.
Susanna Maria ZuurbierStroke Unit and Neurovascular Centre, Department of Neurology, Antwerp University Hospital, Antwerp, Belgium.
Alessandro PadovaniDepartment of Continuity of Care and Frailty, Neurology Unit, ASST Spedali Civili di Brescia, Brescia, Italy.
Andrea MorottiDepartment of Continuity of Care and Frailty, Neurology Unit, ASST Spedali Civili di Brescia, Brescia, Italy.
Piergiorgio LochnerDepartment of Neurology, Saarland University Medical Centre, Homburg, Germany.
Maurizio AcampaStroke Unit, Department of Medical Sciences, Surgery and Neurosciences, University of Siena, Siena, Italy.
Rossana TassiStroke Unit, Department of Medical Sciences, Surgery and Neurosciences, University of Siena, Siena, Italy.
Francesca GuideriStroke Unit, Department of Medical Sciences, Surgery and Neurosciences, University of Siena, Siena, Italy.
Alberto ChitiNeurology Unit, Ospedale Apuano, Massa Carrara, Italy.
Maurizio PaciaroniStroke Unit and Division of Cardiovascular Medicine, University of Perugia, Perugia, Italy.
Maria Giulia MosconiStroke Unit and Division of Cardiovascular Medicine, University of Perugia, Perugia, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

aimCurrent data regarding the effect of intravenous thrombolysis (IVT) in patients with acute ischaemic stroke (AIS) with concomitant malignancy remain unclear. This study aimed to evaluate the efficacy and safety of IVT in patients with AIS and concomitant active cancer.

methodsThe ITACA-stroke study was a retrospective observational study based on prospective registries of a multicentre international collaboration. Patients with a diagnosis of active cancer and AIS, treated or not with IVT, were enrolled. Multivariable logistic regression analysis was performed to identify independent predictors for functional outcomes (mortality and good functional outcome) and haemorrhagic events at 90 days. A propensity score matching (PSM) analysis compared IVT and no-IVT patients.

resultsA total of 521 patients were included, 225 were treated with IVT and 296 were not treated with IVT. IVT was directly correlated with good functional outcome (OR: 2.56, 95% CI 1.45-4.52, p = 0.001), intracranial haemorrhage (ICH) (OR: 4.85, 95% CI: 2.09-11.22, p < 0.001) any haemorrhagic event (OR: 4.13, 95% CI: 1.99-8.57, p < 0.001), and inversely correlated with mortality (OR: 0.41, 95% CI: 0.22-0.74, p = 0.003). In the PSM comparison, IVT was directly associated with good functional outcome (OR: 2.09, 95% CI: 1.16-3.77, p = 0.014) and inversely correlated with mortality (OR: 0.31, 95% CI: 0.15-0.64, p = 0.001), but was not directly associated with haemorrhagic outcomes.

conclusionsTreatment with IVT could be beneficial in patients with AIS and active cancer in terms of functional outcome and mortality. An association between IVT and the risk of haemorrhagic events was less clearly defined in this sample.

Indexed as

Fibrinolytic AgentsIschemic StrokeNeoplasmsThrombolytic TherapyAdministration, IntravenousAgedAged, 80 and overFemaleHumansIntracranial HemorrhagesMaleMiddle AgedRegistriesRetrospective StudiesTreatment OutcomeFibrinolytic AgentsAcute ischaemic strokeCancerFunctional outcomeRisk of bleedingThrombolysis

Identifiers

PMID41128926
PMCPMC12549749

What Socratic holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.