Evidence map›Paper›PMID 41128933›Full record

ArticleSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2025

Stem cell transplant and graft versus host disease: designing and implementing a steroid-induced hyperglycemia tool kit.

Linda Baer, Caitlin Omoregie, Frank Oley, Regina Carlisle, Christina Luszcak, Julia Blanchette, Claudia Lewis, Molly Gallogly, Susan Mazanec

Abstract read
PubMed Publisher
In one paragraph

Article in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Linda BaerUniversity Hospitals Seidman Cancer Center, Cleveland, OH, USA. Linda.baer@uhhospitals.org.
Caitlin OmoregieUniversity Hospitals Cleveland Medical Center, Cleveland, OH, USA.
Frank OleyDepartment of Pharmacy Services, University Hospitals Seidman Cancer Center, Cleveland, OH, USA.
Regina CarlisleUniversity Hospitals Seidman Cancer Center, Cleveland, OH, USA.
Christina LuszcakUniversity Hospitals Seidman Cancer Center, Cleveland, OH, USA.
Julia BlanchetteUH Diabetes & Metabolic Care Center, Cleveland, OH, USA.
Claudia LewisUniversity Hospitals Cleveland Medical Center, Cleveland, OH, USA.
Molly GalloglyUniversity Hospitals Seidman Cancer Center, Case Western Reserve University, Cleveland, OH, USA.
Susan MazanecUniversity Hospitals Seidman Cancer Center, Case Western Reserve University, Cleveland, OH, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposePatients receiving glucocorticoids for acute graft versus host disease (GVHD) after allogeneic hematopoietic stem cell transplant (HSCT) are at risk for developing hyperglycemia and subsequent complications. The primary purpose of this project was to reduce time to medical intervention for steroid-induced hyperglycemia through the implementation of a tailored tool kit for HSCT clinicians.

methodsAn interdisciplinary team conducted a four-phase project: (1) a baseline chart audit and survey of advanced practice providers (APPs), (2) development of a tool kit and educational materials, (3) education of the HSCT team, and (4) post tool kit implementation chart audit and APP surveys.

resultsPatients at baseline (N = 15) and post tool kit implementation (N = 8) were diagnosed with acute GVHD with ≥ 0.5 mg/kg/day prednisone and subsequent steroid-induced hyperglycemia. The average number of days to medical intervention was 46 at baseline, reduced to 10 days at 3 months and 9 days at 6 months post tool kit implementation. Metrics used to evaluate changes in APP practice noted an increase in hemoglobin A1c and glucose monitoring from baseline to post tool kit implementation. There was no change in APP confidence scores pre and post tool kit (N = 29).

conclusionThe tool kit designed in this study is an evidence-based resource created by an interdisciplinary team that led to earlier intervention to improve glycemic control in HSCT patients. Due to the complex nature of HSCT patients, a proactive and stepwise approach to managing hyperglycemia is critical to monitoring patients at risk and initiating treatment early to mitigate symptoms.

Indexed as

GlucocorticoidsGraft vs Host DiseaseHematopoietic Stem Cell TransplantationHyperglycemiaPrednisoneAdultBlood GlucoseFemaleGlycated HemoglobinHumansMaleMiddle AgedTime FactorsBlood GlucoseGlucocorticoidsGlycated HemoglobinPrednisoneAcute graft versus host diseaseAllogeneic hematopoietic stem cell transplantDiabetes managementSteroid-induced hyperglycemia

Identifiers

PMID41128933

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.