Evidence map›Paper›PMID 41130992›Full record

Trial reportScientific reports2025

Cortical excitability and analgesic effects of multisite transcranial direct current stimulation targeting the motor cortex and cerebellum in fibromyalgia.

Daniel Fernando Arias Betancur, Maria da Graça Lopes Tarragó, Bárbara Regina França, Graziele Borges Bueno, Júlia Gomes, Mariana Lentino Coelho, Caroline Leffa Venturini, Iraci L S Torres, Felipe Fregni, Hugo Bock and 1 more

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Daniel Fernando Arias BetancurGraduate Program in Medical Sciences, School of Medicine, Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, Brazil.
Maria da Graça Lopes TarragóPhysical Medicine and Rehabilitation Service, Hospital de Clínicas de Porto Alegre (HCPA), Porto Alegre, Brazil.
Bárbara Regina FrançaLaboratory of Pain & Neuromodulation, Clinical Research Center, Hospital de Clínicas de Porto Alegre (HCPA) at UFRGS, Ramiro Barcelos, 2350, Bairro Rio Branco, Porto Alegre, CEP 90035-003, RS, Brazil.
Graziele Borges BuenoLaboratory of Pain & Neuromodulation, Clinical Research Center, Hospital de Clínicas de Porto Alegre (HCPA) at UFRGS, Ramiro Barcelos, 2350, Bairro Rio Branco, Porto Alegre, CEP 90035-003, RS, Brazil.
Júlia GomesLaboratory of Pain & Neuromodulation, Clinical Research Center, Hospital de Clínicas de Porto Alegre (HCPA) at UFRGS, Ramiro Barcelos, 2350, Bairro Rio Branco, Porto Alegre, CEP 90035-003, RS, Brazil.
Mariana Lentino CoelhoLaboratory of Pain & Neuromodulation, Clinical Research Center, Hospital de Clínicas de Porto Alegre (HCPA) at UFRGS, Ramiro Barcelos, 2350, Bairro Rio Branco, Porto Alegre, CEP 90035-003, RS, Brazil.
Caroline Leffa VenturiniLaboratory of Pain & Neuromodulation, Clinical Research Center, Hospital de Clínicas de Porto Alegre (HCPA) at UFRGS, Ramiro Barcelos, 2350, Bairro Rio Branco, Porto Alegre, CEP 90035-003, RS, Brazil.
Iraci L S TorresGraduate Program in Medical Sciences, School of Medicine, Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, Brazil.
Felipe FregniLaboratory of Neuromodulation and Center for Clinical Research Learning, Physics and Rehabilitation Department, Spaulding Rehabilitation Hospital, Boston, MA, USA.
Hugo BockCentro de Pesquisa Experimental (CPE), Unidade de Pesquisa Laboratorial, Hospital de Clínicas de Porto Alegre (HCPA), Porto Alegre, Brazil.
Wolnei CaumoGraduate Program in Medical Sciences, School of Medicine, Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, Brazil. wcaumo@hcpa.edu.br.

Funding

CAPES 2022-2023CNPq 306606/2021-6
6 · The paper itself

Abstract

This double-blind, sham-controlled randomized clinical trial investigated whether a single session of anodal-(a) transcranial direct current stimulation (tDCS), applied over the primary motor cortex (M1), cerebellum (CB), or both, would reduce pain and increase corticospinal excitability more effectively than sham stimulation (s-tDCS). Ninety-two women with fibromyalgia were randomized to a single session of anodal-(a)-tDCS or sham-(s)-tDCS. Primary outcomes were pain intensity, assessed with the Numerical Pain Scale (NPS), and corticospinal excitability, measured by motor evoked potentials (MEP). Compared to sham, a-tDCS significantly reduced NPS scores (Wald χ

Indexed as

CerebellumCortical ExcitabilityFibromyalgiaMotor CortexTranscranial Direct Current StimulationAdultDouble-Blind MethodEvoked Potentials, MotorFemaleHumansMiddle AgedPain ManagementPain MeasurementTreatment OutcomeBDNFCerebellumFibromyalgiaMEPPaintDCS

Identifiers

PMID41130992
PMCPMC12549915

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.