Evidence map›Paper›PMID 41131221›Full record

ArticleScientific reports2025

Insights from 24-hour actigraphy using functional linear modeling in children with and without ADHD.

Mirjam Ziegler, Pascal Maurice Aggensteiner, Katja Becker, Manfred Döpfner, Julia Geissler, Sarah Hohmann, Reto Huber, Christine Igel, Karina Janson, Konstantin Mechler and 5 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Mirjam ZieglerDepartment of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany. Mirjam.Ziegler@zi-mannheim.de.
Pascal Maurice AggensteinerDepartment of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Katja BeckerDepartment of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University of Marburg and University Hospital Marburg (UKGM), Marburg, Germany.
Manfred DöpfnerCenter for Child and Adolescent Cognitive Behavior Therapy (CEKiP), Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
Julia GeisslerDepartment of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University Hospital Wuerzburg, Wuerzburg, Germany.
Sarah HohmannDepartment of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Reto HuberChild Development Center and Pediatric Sleep Disorders Center, University Children's Hospital Zürich - Eleonore Foundation, University of Zürich, Zurich, Switzerland.
Christine IgelDepartment of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Karina JansonDepartment of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Konstantin MechlerDepartment of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Sabina MillenetDepartment of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Marcel RomanosDepartment of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University Hospital Wuerzburg, Wuerzburg, Germany.
Daniel BrandeisDepartment of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Tobias BanaschewskiDepartment of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Anna KaiserDepartment of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sleep problems and alterations in circadian rhythmicity have been widely reported in attention-deficit/hyperactivity disorder (ADHD) patients, but studies covering the full 24h-motor-activity patterns to explore whole-day activity cycles are scarce. Furthermore, correlates and predictors of (hyper-)activity patterns are largely unknown. A subsample of 74 children (6-12 years) with ADHD (n = 35) participating in the multicenter study ESCAlife and n = 39 controls recruited in one center were assessed using 24h-actigraphy for two weeks. Functional linear modeling (FLM) was applied to the actigraphy data and further post-hoc correlational analyses were conducted. FLM revealed no significant differences in 24h-actigraphy profiles between children with and without ADHD, but differentiated between ADHD presentations (combined vs. inattentive) around sleep onset time (around 8:00p.m.) on free days. In the ADHD group, the 24h-actigraphy profiles were associated with measures of the chronotype and early regulation problems in toddler age; in the control group, with daylight exposure. Finding 24h-activity profile differences between ADHD presentations, but not between ADHD and control children as in classical analyses of sleep-onset latency suggests that comprehensive 24h-FLM analyses and focused sleep-related analyses of actigraphy data capture complementary aspects altered in ADHD and its presentations. Another limitation is that the majority of children with ADHD were medicated. However, actigraphy may still prove valuable as a supplementary diagnostic tool in clinical ADHD assessment.

Indexed as

ActigraphyAttention Deficit Disorder with HyperactivityCircadian RhythmCase-Control StudiesChildFemaleHumansLinear ModelsMaleSleep24h-actigraphyAttention-deficit/hyperactivity disorder (ADHD)ChildrenCircadian rhythmicityESCAlifeFunctional linear modeling (FLM)

Identifiers

PMID41131221
PMCPMC12550039

What Socratic holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.