Evidence map›Paper›PMID 41131362›Full record

ArticleNature neuroscience2025

Cortical and subcortical mapping of the human allostatic-interoceptive system using 7 Tesla fMRI.

Jiahe Zhang, Danlei Chen, Philip Deming, Tara Srirangarajan, Jordan E Theriault, Philip A Kragel, Ludger Hartley, Kent M Lee, Kieran McVeigh, Tor D Wager and 6 more

Abstract read
In one paragraph

Article in Nature neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Categorization is 'baked' into the brain.Nature reviews. Neuroscience · 2026
    Review
  5. Article
  6. Article
  7. Hypnotizability and Time Reproduction.Cerebellum (London, England) · 2026
    Article
  8. Article
  9. Article
  10. Article
  11. Uncovering the embodied dimension of the wandering mind.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  12. Article
  13. Article
  14. Article
  15. Interoception network in the rat brain.Imaging neuroscience (Cambridge, Mass.) · 2026
    Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors.

Jiahe ZhangDepartment of Psychology, Northeastern University, Boston, MA, USA. j.zhang@northeastern.edu.ORCID http://orcid.org/0000-0002-7520-074X
Danlei ChenDepartment of Psychology, Northeastern University, Boston, MA, USA.
Philip DemingDepartment of Psychology, Northeastern University, Boston, MA, USA.ORCID http://orcid.org/0000-0002-0512-9263
Tara SrirangarajanDepartment of Psychology, Stanford University, Stanford, CA, USA.ORCID http://orcid.org/0000-0002-7435-6347
Jordan E TheriaultDepartment of Psychology, Northeastern University, Boston, MA, USA.
Philip A KragelDepartment of Psychology, Emory University, Atlanta, GA, USA.ORCID http://orcid.org/0000-0001-9463-6381
Ludger HartleyDepartment of Psychology, Northeastern University, Boston, MA, USA.
Kent M LeeDepartment of Psychology, Northeastern University, Boston, MA, USA.
Kieran McVeighDepartment of Psychology, Northeastern University, Boston, MA, USA.
Tor D WagerDepartment of Psychological and Brain Sciences, Dartmouth College, Hanover, NH, USA.ORCID http://orcid.org/0000-0002-1936-5574
Lawrence L WaldDepartment of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston, MA, USA.ORCID http://orcid.org/0000-0001-8278-6307
Ajay B SatputeDepartment of Psychology, Northeastern University, Boston, MA, USA.
Karen S QuigleyDepartment of Psychology, Northeastern University, Boston, MA, USA.ORCID http://orcid.org/0000-0001-8844-990X
Susan Whitfield-GabrieliDepartment of Psychology, Northeastern University, Boston, MA, USA.
Lisa Feldman BarrettDepartment of Psychology, Northeastern University, Boston, MA, USA. l.barrett@northeastern.edu.
Marta BianciardiDepartment of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston, MA, USA. martab@mgh.harvard.edu.ORCID http://orcid.org/0000-0001-9606-6853

Funding

Affect regulation and Beta Amyloid: Maturational Factors in Aging and Age-Related PathologyR01MH113234 · NIMH · NORTHEASTERN UNIVERSITY · PI DICKERSON, BRADFORD C, ISAACOWITZ, DEREK M · 2017 to 2021
$4.2M
Biopsychosocial Mechanisms of Successful AgingR01AG071173 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI Lisa Feldman Barrett, BRADFORD C DICKERSON · 2022 to 2026
$3.9M
Brainstem-based imaging biomarkers of premanifest synucleinopathyR01AG063982 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI BIANCIARDI, MARTA · 2020 to 2024
$3.6M
Ovarian Effects on Intrinsic Connectivity and the Affective Enhancement of MemoryR01MH109464 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI ANDREANO, JOSEPH M, BARRETT, LISA FELDMAN · 2017 to 2021
$3.5M
Fundamental subcortical mechanisms of affective processingU01CA193632 · NCI · NORTHEASTERN UNIVERSITY · PI BARRETT, LISA FELDMAN, SATPUTE, AJAY · 2016 to 2020
$3.0M
The neural bases of placebo effects and their relation to regulatory processesR37MH076136 · NIMH · DARTMOUTH COLLEGE · PI TOR D. WAGER · 2024 to 2026
$2.4M
In vivo atlas of the ascending arousal system in health and traumatic comaK01EB019474 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI BIANCIARDI, MARTA · 2016 to 2019
$691k
In vivo mapping of human brainstem vestibular and autonomic pathwaysR21DC015888 · NIDCD · MASSACHUSETTS GENERAL HOSPITAL · PI BIANCIARDI, MARTA · 2017 to 2018
$470k
Probing negative affect circuits in humans using 7T fMRIF32MH133288 · NIMH · NORTHEASTERN UNIVERSITY · PI DEMING, PHILIP · 2023 to 2025
$232k
National Science Foundation (NSF) BCS 1947972NCI NIH HHS U01 CA193632NIA NIH HHS R01 AG063982NIA NIH HHS R01 AG071173NIBIB NIH HHS K01 EB019474NIDCD NIH HHS R21 DC015888NIMH NIH HHS F32 MH133288NIMH NIH HHS R01 MH109464NIMH NIH HHS R01 MH113234NIMH NIH HHS R37 MH076136U.S. Department of Health & Human Services | National Institutes of Health (NIH) NIDCD R21 DC015888, NIBIB K01 EB019474, NIA R01 AG063982U.S. Department of Health & Human Services | National Institutes of Health (NIH) U01 CA193632, R01 AG071173, R01 MH109464, R01 MH113234
6 · The paper itself

Abstract

The brain continuously anticipates the body's energetic needs and prepares to meet them before they arise-a process called allostasis. To support allostasis, the brain continually models the body's sensory state, a process known as interoception. Here we replicate and extend a large-scale system that supports allostasis and interoception in the human brain using ultrahigh precision 7 Tesla functional magnetic resonance imaging (n = 90), improving precision in subgenual and pregenual anterior cingulate topography and expanding brainstem nuclei mapping. Our functional connectivity analyses provide corroborating evidence for more than 96% of the anatomical connections documented in nonhuman animal tract-tracing studies. This system also includes regions of dense intrinsic connectivity throughout the system, some of which were identified previously as part of the backbone of neural communication across the brain. These results reinforce the existing evidence for a whole-brain system that supports the modeling and regulation of the body's internal milieu.

Indexed as

AllostasisBrainBrain MappingCerebral CortexInteroceptionMagnetic Resonance ImagingAdultFemaleHumansMaleNeural PathwaysYoung Adult

Identifiers

PMID41131362
PMCPMC12586188

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.